ID   SAS5_CAEBR              Reviewed;         403 AA.
AC   Q60M48; A8Y485;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Spindle assembly abnormal protein 5;
GN   Name=sas-5; ORFNames=CBG23306;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for centrosome duplication. Essential for daughter-
CC       centriole formation. Requires both maternal and partenal expression,
CC       suggesting that it regulates centriole duplication during both
CC       spermatogenesis and early embryogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with sas-6 via its coiled coil domain.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, centrosome, centriole {ECO:0000250}.
CC       Note=Localizes to centrioles. Shuttles between centrioles and the
CC       cytoplasm throughout the cell cycle. Requires zyg-1 for centriole
CC       localization (By similarity). {ECO:0000250}.
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DR   EMBL; HE601533; CAP39705.3; -; Genomic_DNA.
DR   RefSeq; XP_002636604.1; XM_002636558.1.
DR   AlphaFoldDB; Q60M48; -.
DR   SMR; Q60M48; -.
DR   STRING; 6238.CBG23306; -.
DR   EnsemblMetazoa; CBG23306.1; CBG23306.1; WBGene00041682.
DR   GeneID; 8578599; -.
DR   KEGG; cbr:CBG_23306; -.
DR   CTD; 8578599; -.
DR   WormBase; CBG23306; CBP12393; WBGene00041682; Cbr-sas-5.
DR   eggNOG; ENOG502SXK9; Eukaryota.
DR   HOGENOM; CLU_057198_0_0_1; -.
DR   InParanoid; Q60M48; -.
DR   OMA; IDSRQWT; -.
DR   OrthoDB; 1231662at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007099; P:centriole replication; IEA:EnsemblMetazoa.
PE   3: Inferred from homology;
KW   Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Reference proteome.
FT   CHAIN           1..403
FT                   /note="Spindle assembly abnormal protein 5"
FT                   /id="PRO_0000097594"
FT   REGION          24..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          128..163
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        24..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..396
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  46553 MW;  C1612AA5591B5DEB CRC64;
     MSNYDRVPCS IAIPNQQVEI QQQPRVFEDQ ESPVKTKVQQ PPPEQVRVPP TVIGATATAK
     KKSCLSTTSS RKEPPAHPAL RRKTVAFGRT VNVSQTVEGT SRHTKKAIAS PSQNHRMTEE
     NQEENWRDVM KNEFEVMRKE MQEEATKKQE ELNAQNLNKM QEMMSQFFQQ ITVAKPSAEE
     SQDREKENWY EQSRHARQQK PANKIAKARE IIKREGSIPP EALPILEQRI RTDPMFRQQI
     DNVLADAECD ANRAAYSPLP PLSPPSGRYA NGSSGNPALM RETLTVERSI RYDNGLSSID
     SRQWTSERND NRTHDNYRPY EPDPQLQSMY QKGQSVSYYP SEAVGKAHRN NRLEYHVEEV
     PEYEEEETEV GGRGRGRKYH EPMETESAAE RERRIREKYS RRK