ID   SAS6_CAEBR              Reviewed;         489 AA.
AC   Q60P76; A8Y240;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 3.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Spindle assembly abnormal protein 6;
GN   Name=sas-6; ORFNames=CBG22377;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Central scaffolding component of the centrioles ensuring
CC       their 9-fold symmetry. Required for centrosome biogenesis and
CC       duplication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Nine homodimers form a cartwheel structure with an internal
CC       diameter of 23 nM and radial spokes connecting to the microtubule
CC       triplets. Interacts with sas-5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, centrosome, centriole {ECO:0000250}.
CC       Note=Localizes to centrioles. {ECO:0000250}.
CC   -!- DOMAIN: The coiled coil domain is necessary and sufficient for
CC       interaction with sas-5. {ECO:0000250}.
CC   -!- DOMAIN: The 35 nM long coiled-coil domain mediates homodimerization
CC       while the globular N-terminus links the dimers at an angle of 40
CC       degrees to form the inner ring. {ECO:0000250}.
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DR   EMBL; HE600912; CAP38980.3; -; Genomic_DNA.
DR   AlphaFoldDB; Q60P76; -.
DR   SMR; Q60P76; -.
DR   STRING; 6238.CBG22377; -.
DR   PRIDE; Q60P76; -.
DR   EnsemblMetazoa; CBG22377.1; CBG22377.1; WBGene00040950.
DR   WormBase; CBG22377; CBP37617; WBGene00040950; Cbr-sas-6.
DR   eggNOG; ENOG502THXX; Eukaryota.
DR   HOGENOM; CLU_565286_0_0_1; -.
DR   InParanoid; Q60P76; -.
DR   OMA; WTAQITT; -.
DR   OrthoDB; 1071936at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007099; P:centriole replication; IEA:EnsemblMetazoa.
DR   GO; GO:0008104; P:protein localization; IEA:EnsemblMetazoa.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblMetazoa.
DR   Gene3D; 2.170.210.20; -; 1.
DR   InterPro; IPR032396; SAS-6_N.
DR   InterPro; IPR038558; SAS-6_N_sf.
DR   Pfam; PF16531; SAS-6_N; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Reference proteome.
FT   CHAIN           1..489
FT                   /note="Spindle assembly abnormal protein 6"
FT                   /id="PRO_0000189977"
FT   DOMAIN          45..97
FT                   /note="PISA"
FT   REGION          470..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          187..409
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   489 AA;  55791 MW;  4F654A0A6A3201F2 CRC64;
     MTSRLALFDQ TLSASLLQRV NSDPHDYKAY KTRVKLKILE QRGEHGEKEL KFEISRADDF
     EFLFAAILNN EKYQELAKAH ELTVDFDTFP KVIIQHLLCK NIVKTADEDG IEVDARAKPG
     YHSIIENRGV PPTEINIKLE KDKNSCEFEI FSKTPISKGK IFAMSLQAVR GDLLIAHLLK
     ICSSQSTKIA TLHRSTDELA ALKTKVAEME KRNQSIEDLE KKIEEQEERI REMEDELELV
     KEERENIRVI AEEKEDLVAE LQNDLESVNR ELEENQEELE IVGKMLGEEQ GKVDQLQKRN
     VAHQKELATL QRNFQKVESQ LKRSSVEQSQ QSLDIRKLRE LEADLKEKDS MVENLTQTVG
     ILKKELEDER VKMQETMTSF ESLKVENESV KERLAMYRNQ RFSPAPVGLQ TTTIPSAGVG
     FKTVLGQNSP YANNPNMRTP FRDTSSALNT GLTYQNSITP LPNTTRFLMA DDTTGSSVTN
     TPPVLRNPL