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SAS6_DANRE
ID   SAS6_DANRE              Reviewed;         627 AA.
AC   Q7ZVT3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Spindle assembly abnormal protein 6 homolog;
GN   Name=sass6; Synonyms=sas6; ORFNames=zgc:55668;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 1-179, FUNCTION, SUBCELLULAR
RP   LOCATION, SUBUNIT, AND DOMAIN.
RX   PubMed=21273447; DOI=10.1126/science.1199325;
RA   van Breugel M., Hirono M., Andreeva A., Yanagisawa H.A., Yamaguchi S.,
RA   Nakazawa Y., Morgner N., Petrovich M., Ebong I.O., Robinson C.V.,
RA   Johnson C.M., Veprintsev D., Zuber B.;
RT   "Structures of SAS-6 suggest its organization in centrioles.";
RL   Science 331:1196-1199(2011).
CC   -!- FUNCTION: Central scaffolding component of the centrioles ensuring
CC       their 9-fold symmetry (PubMed:21273447). Required for centrosome
CC       biogenesis and duplication: required both for mother-centriole-
CC       dependent centriole duplication and deuterosome-dependent centriole
CC       amplification in multiciliated cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q6UVJ0, ECO:0000269|PubMed:21273447}.
CC   -!- SUBUNIT: Nine homodimers form a cartwheel structure with an internal
CC       diameter of 23 nM and radial spokes connecting to the microtubule
CC       triplets. {ECO:0000269|PubMed:21273447}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000269|PubMed:21273447}. Note=Component of the
CC       deuterosome, a structure that promotes de novo centriole amplification
CC       in multiciliated cells that can generate more than 100 centrioles.
CC       {ECO:0000250|UniProtKB:Q6NRG6}.
CC   -!- DOMAIN: The 35 nM long coiled-coil domain mediates homodimerization
CC       while the globular N-terminus links the dimers at an angle of 40
CC       degrees to form the inner ring. {ECO:0000269|PubMed:21273447}.
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DR   EMBL; BC045420; AAH45420.1; -; mRNA.
DR   RefSeq; NP_998603.1; NM_213438.1.
DR   PDB; 2Y3V; X-ray; 1.92 A; A/B/C/D=1-156.
DR   PDB; 2Y3W; X-ray; 1.98 A; A/B/C=1-179.
DR   PDB; 6Z26; X-ray; 2.32 A; A/B/C/D=243-358.
DR   PDBsum; 2Y3V; -.
DR   PDBsum; 2Y3W; -.
DR   PDBsum; 6Z26; -.
DR   AlphaFoldDB; Q7ZVT3; -.
DR   SMR; Q7ZVT3; -.
DR   ComplexPortal; CPX-1154; CPAP-STIL complex.
DR   STRING; 7955.ENSDARP00000075634; -.
DR   PaxDb; Q7ZVT3; -.
DR   GeneID; 406747; -.
DR   KEGG; dre:406747; -.
DR   CTD; 163786; -.
DR   ZFIN; ZDB-GENE-040426-2784; sass6.
DR   eggNOG; ENOG502QQ4W; Eukaryota.
DR   InParanoid; Q7ZVT3; -.
DR   OrthoDB; 345225at2759; -.
DR   PhylomeDB; Q7ZVT3; -.
DR   EvolutionaryTrace; Q7ZVT3; -.
DR   PRO; PR:Q7ZVT3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; IDA:ZFIN.
DR   GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR   GO; GO:0098536; C:deuterosome; ISS:UniProtKB.
DR   GO; GO:0120099; C:procentriole replication complex; IC:ComplexPortal.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0051298; P:centrosome duplication; IMP:ZFIN.
DR   GO; GO:0040016; P:embryonic cleavage; IMP:ZFIN.
DR   GO; GO:0007052; P:mitotic spindle organization; IMP:ZFIN.
DR   GO; GO:0000280; P:nuclear division; IMP:ZFIN.
DR   GO; GO:0046601; P:positive regulation of centriole replication; IC:ComplexPortal.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IC:ComplexPortal.
DR   GO; GO:0110028; P:positive regulation of mitotic spindle organization; IC:ComplexPortal.
DR   GO; GO:1905832; P:positive regulation of spindle assembly; IC:ComplexPortal.
DR   GO; GO:0007283; P:spermatogenesis; IMP:ZFIN.
DR   Gene3D; 2.170.210.20; -; 1.
DR   InterPro; IPR032396; SAS-6_N.
DR   InterPro; IPR038558; SAS-6_N_sf.
DR   InterPro; IPR041513; SAS6_CC.
DR   Pfam; PF16531; SAS-6_N; 1.
DR   Pfam; PF18594; Sas6_CC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..627
FT                   /note="Spindle assembly abnormal protein 6 homolog"
FT                   /id="PRO_0000189975"
FT   DOMAIN          39..91
FT                   /note="PISA"
FT   REGION          187..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          153..473
FT                   /evidence="ECO:0000255"
FT   STRAND          2..15
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          17..19
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          22..33
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          36..40
FT                   /evidence="ECO:0007829|PDB:2Y3W"
FT   STRAND          43..50
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          53..62
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   HELIX           64..74
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   HELIX           80..82
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   HELIX           83..97
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          100..102
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          104..110
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          115..117
FT                   /evidence="ECO:0007829|PDB:2Y3W"
FT   STRAND          121..127
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   STRAND          134..143
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   HELIX           146..153
FT                   /evidence="ECO:0007829|PDB:2Y3V"
FT   HELIX           256..348
FT                   /evidence="ECO:0007829|PDB:6Z26"
SQ   SEQUENCE   627 AA;  71315 MW;  068636706A28E4E7 CRC64;
     MTELLFNKRL QVLVKSKDTD ERRSVIRVSI ELQLPSSPVH RKDLVVRLTD DTDLYFLYNL
     IISEEDFQSL KVQQGLLIDF TSFPQKFIDL LEQCICEQDK ESPRFLLQLS SSSSAFDHSP
     SNLNIVETNA FKHLTHLSLK LLPGSDTDIK KYLASCLSSV KEEKQQLQQK LRKTEEDLTR
     QLNYAQQTLS EKSRELDKLR SEWTSQTTSL SSRHMQDLTA EREKALETQS RLQQQNEQLR
     QELESSHHRS TQQLQTKVSE LETANRELID KKYKSDSTIR DLKAKLTSLE EECQRSKQQV
     LSLRRENSAL DSECHEKERL LNQLQTRVAV LEQEIKDKDQ LVLRTKEVLE ATQQQKNSVE
     GNAESKQLQI SKLESTVKSL SEELIKANGI IKKLQADLKA LLGKIKVKNS VTVPQEKILQ
     ETSDKLQRQQ RELQDTQQRL SLKEEEAAKL KEQLEATVQK LDESREVLKT NENVITWLNK
     QLNENQLSRK QETVAMFETP AAALRSAAVP HNMAFPITST INSKYPLALS CVSSGSRSVL
     TSSNGPKVQF NPMSVKPSAA EVSPAAFSQP ANKENSEPVG LDSKYFERRD DSIPLRGLLP
     SMHLNREVPK PLNTAAAKAT PSAFFPG
 
 
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