ID   SASA_CROS5              Reviewed;         382 AA.
AC   B1WYT4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE            EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE   AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN   Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=cce_1751;
OS   Crocosphaera subtropica (strain ATCC 51142 / BH68) (Cyanothece sp. (strain
OS   ATCC 51142)).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Crocosphaera; Crocosphaera subtropica.
OX   NCBI_TaxID=43989;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51142 / BH68;
RX   PubMed=18812508; DOI=10.1073/pnas.0805418105;
RA   Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C.,
RA   Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K.,
RA   Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B.;
RT   "The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium
RT   important in the marine nitrogen cycle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008).
CC   -!- FUNCTION: May be involved in signal transduction. Participates in the
CC       KaiABC clock protein complex, which constitutes the main circadian
CC       regulator in cyanobacteria, via its interaction with KaiC. Required for
CC       robustness of the circadian rhythm of gene expression and is involved
CC       in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC   -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC       core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC       dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR   EMBL; CP000806; ACB51101.1; -; Genomic_DNA.
DR   RefSeq; WP_009545566.1; NC_010546.1.
DR   AlphaFoldDB; B1WYT4; -.
DR   SMR; B1WYT4; -.
DR   STRING; 43989.cce_1751; -.
DR   EnsemblBacteria; ACB51101; ACB51101; cce_1751.
DR   KEGG; cyt:cce_1751; -.
DR   eggNOG; COG2205; Bacteria.
DR   HOGENOM; CLU_723030_0_0_3; -.
DR   OMA; AHYGQIW; -.
DR   OrthoDB; 1755994at2; -.
DR   Proteomes; UP000001203; Chromosome circular.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd02978; KaiB_like; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_01837; Kinase_SasA; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR011649; KaiB_domain.
DR   InterPro; IPR023527; Kinase_SasA.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF07689; KaiB; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM01248; KaiB; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Kinase; Phosphoprotein; Reference proteome;
KW   Transferase; Two-component regulatory system.
FT   CHAIN           1..382
FT                   /note="Adaptive-response sensory-kinase SasA"
FT                   /id="PRO_1000188349"
FT   DOMAIN          160..382
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT   MOD_RES         163
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ   SEQUENCE   382 AA;  43730 MW;  8B519C6C1F987165 CRC64;
     MLEPPNHQTT AKTDQAASMS IQLLLFVDER PSSHEYIQPI RDYIKTVSQD CPCQLEVIEI
     HEQPHLVEHF RLVATPALVK VVPEPRQTLA GSNLVNQLKK WWPKWLSSLE ENHHDSLLEK
     SSNVGYSGEL MRLSDEIFRL KKDKENLQEQ LKFKDQVLAM LAHDLRSPLT AASIAVETLE
     LAKNQDPTEK QQKLTAQLFN QTRNQFRVMN RLITDILQAS KSMNAQLQVH QTEVFLPRLS
     KEIVEQYNDL LTEKSLKLIQ DVPQDVPGVY ADEELIRQVI VNLIDNAIKY TSEGGEITLS
     ILHRTSQKVQ VSVCDTGPGI PEEKQERIFE GHFRLQRDQG KEGYGLGLSL CRKIIRVHYG
     QIWVDSVPGQ GSCFHFTLPV YR