ID   SASA_MICAN              Reviewed;         384 AA.
AC   B0JK50;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE            EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE   AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN   Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=MAE_60820;
OS   Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Microcystaceae; Microcystis.
OX   NCBI_TaxID=449447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-843 / IAM M-247;
RX   PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA   Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA   Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA   Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA   Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT   "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT   Microcystis aeruginosa NIES-843.";
RL   DNA Res. 14:247-256(2007).
CC   -!- FUNCTION: May be involved in signal transduction. Participates in the
CC       KaiABC clock protein complex, which constitutes the main circadian
CC       regulator in cyanobacteria, via its interaction with KaiC. Required for
CC       robustness of the circadian rhythm of gene expression and is involved
CC       in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC   -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC       core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC       dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR   EMBL; AP009552; BAG05904.1; -; Genomic_DNA.
DR   RefSeq; WP_012268234.1; NC_010296.1.
DR   AlphaFoldDB; B0JK50; -.
DR   SMR; B0JK50; -.
DR   STRING; 449447.MAE_60820; -.
DR   PaxDb; B0JK50; -.
DR   EnsemblBacteria; BAG05904; BAG05904; MAE_60820.
DR   KEGG; mar:MAE_60820; -.
DR   PATRIC; fig|449447.4.peg.5568; -.
DR   eggNOG; COG2205; Bacteria.
DR   HOGENOM; CLU_723030_0_0_3; -.
DR   OMA; AHYGQIW; -.
DR   OrthoDB; 1755994at2; -.
DR   BioCyc; MAER449447:MAE_RS26550-MON; -.
DR   Proteomes; UP000001510; Chromosome.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd02978; KaiB_like; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_01837; Kinase_SasA; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR011649; KaiB_domain.
DR   InterPro; IPR023527; Kinase_SasA.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF07689; KaiB; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM01248; KaiB; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Kinase; Phosphoprotein; Reference proteome;
KW   Transferase; Two-component regulatory system.
FT   CHAIN           1..384
FT                   /note="Adaptive-response sensory-kinase SasA"
FT                   /id="PRO_1000088440"
FT   DOMAIN          162..384
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT   MOD_RES         165
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ   SEQUENCE   384 AA;  44103 MW;  D54D459FEE9EDDD4 CRC64;
     MLPSNEPLTA LGRETTTPLS IQLLLFVDDR PSSQEIIRQI QSYLQSLKSD YPIDLQIIEI
     RQQPHLVEHF RLVATPALVK IAPGPRHTLA GSNLVEQFKK WLVRWQKAIK EEVKNHHAED
     AQLQEVEHSG ELIRIADEVF RLKQEKEELL EQLKFKDQIL AMLAHDLRSP LTAASIAVET
     LELAYHQPDT ERSLQLREQL HQQARKQFRI MNRLITDILQ ASKSMAAQFT LHQSKFYLQS
     LCQEILSQFT DTFQEKTLIF QSDIPQDLPP VYADEELIRQ VIINLLENGI KYTPAGGEIT
     LSVLHRTTQK VQVSISDTGP GIPEEKQEHI FEGHVRLKRD EGKEGYGIGL SVCRKIIRAH
     YGQIWVDSVP DHGSSFHFTL PVYR