SASA_PROM0
ID SASA_PROM0 Reviewed; 372 AA.
AC A3PDI2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=P9301_11841;
OS Prochlorococcus marinus (strain MIT 9301).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=167546;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9301;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: May be involved in signal transduction. Participates in the
CC KaiABC clock protein complex, which constitutes the main circadian
CC regulator in cyanobacteria, via its interaction with KaiC. Required for
CC robustness of the circadian rhythm of gene expression and is involved
CC in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR EMBL; CP000576; ABO17807.1; -; Genomic_DNA.
DR RefSeq; WP_011863135.1; NC_009091.1.
DR AlphaFoldDB; A3PDI2; -.
DR SMR; A3PDI2; -.
DR STRING; 167546.P9301_11841; -.
DR EnsemblBacteria; ABO17807; ABO17807; P9301_11841.
DR KEGG; pmg:P9301_11841; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_723030_0_0_3; -.
DR OMA; AHYGQIW; -.
DR Proteomes; UP000001430; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_01837; Kinase_SasA; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011649; KaiB_domain.
DR InterPro; IPR023527; Kinase_SasA.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF07689; KaiB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM01248; KaiB; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Kinase; Phosphoprotein; Reference proteome;
KW Transferase; Two-component regulatory system.
FT CHAIN 1..372
FT /note="Adaptive-response sensory-kinase SasA"
FT /id="PRO_1000088441"
FT DOMAIN 147..360
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT MOD_RES 150
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ SEQUENCE 372 AA; 42438 MW; 240A90FCA860CE2E CRC64;
MNDKKELKLI LVAARNQLSS NDIKSLIAYL ESDDCEFEIS LQISEPTEQP ELLELHRLVA
IPALIKVSPA PKQIFAGSNI FSQLQKWLPR WTQEGLTKNL GINLQPSKID SIRTQKEFLL
EDELLVLRQE NETLTKRIES QERLLRMVAH ELRTPLTAAT LAVQSQKLGQ IDISKLQEVI
KRRLEEIELL SQDLLEVGTT KWEALFNPQK IDLGNISAEV ILELEKFWRL RNIEIDTDIP
SDLPSVFADQ RRMRQVFLNL IENAIKFSRD SGSIKITMIH KTNQWVEITI CDKGAGIPLS
EQKRIFLDRV RLPQTSEGTS GFGIGLSVCR RIVQVHGGRI WVVSEVGVGS CFHFTVPVWQ
GQNKEQQYLT KG