SASA_PROM2
ID SASA_PROM2 Reviewed; 372 AA.
AC A8G5E7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=P9215_12131;
OS Prochlorococcus marinus (strain MIT 9215).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=93060;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9215;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: May be involved in signal transduction. Participates in the
CC KaiABC clock protein complex, which constitutes the main circadian
CC regulator in cyanobacteria, via its interaction with KaiC. Required for
CC robustness of the circadian rhythm of gene expression and is involved
CC in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR EMBL; CP000825; ABV50828.1; -; Genomic_DNA.
DR RefSeq; WP_012007902.1; NC_009840.1.
DR AlphaFoldDB; A8G5E7; -.
DR SMR; A8G5E7; -.
DR STRING; 93060.P9215_12131; -.
DR EnsemblBacteria; ABV50828; ABV50828; P9215_12131.
DR KEGG; pmh:P9215_12131; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_723030_0_0_3; -.
DR OMA; AHYGQIW; -.
DR OrthoDB; 1755994at2; -.
DR Proteomes; UP000002014; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_01837; Kinase_SasA; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011649; KaiB_domain.
DR InterPro; IPR023527; Kinase_SasA.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF07689; KaiB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM01248; KaiB; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Kinase; Phosphoprotein; Transferase;
KW Two-component regulatory system.
FT CHAIN 1..372
FT /note="Adaptive-response sensory-kinase SasA"
FT /id="PRO_1000088442"
FT DOMAIN 147..360
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT MOD_RES 150
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ SEQUENCE 372 AA; 42455 MW; 94A526089D8EE8D6 CRC64;
MNDKKELKLI LVAARNQLSS GDIKSLIAYL ESNDCEFEIS LQISEPTEQP ELLELHRLVA
IPALIKISPA PKQIFAGSNI FSQFQKWLPR WTQEGLTKNL GINLQPSKID SIRTQKEFLL
EDELLVLRQE NETLTKRIES QERLLRMVAH ELRTPLTAAT LAIQSQKLGQ IDISKLQEVI
KRRLEEIELL SQDLLEVGTT KWEALFNPQK IDLGNISAEV ILELEKFWRL RNIEIDTDIP
SDLPSVFADQ RRMRQVLLNL IENAIKFSED SGSIKITMIH KTNQWVEITI CDKGAGIPLS
EQKRIFLDRV RLPQTSEGTS GFGIGLSVCR RIVQVHGGRI WVVSELSEGS CFHFTVPVWQ
GQNKEQQYLT KG