SASA_PROM9
ID SASA_PROM9 Reviewed; 372 AA.
AC Q31AE8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837};
GN OrderedLocusNames=PMT9312_1088;
OS Prochlorococcus marinus (strain MIT 9312).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=74546;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9312;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F.,
RA Land M., Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of Prochlorococcus marinus str. MIT 9312.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in signal transduction. Participates in the
CC KaiABC clock protein complex, which constitutes the main circadian
CC regulator in cyanobacteria, via its interaction with KaiC. Required for
CC robustness of the circadian rhythm of gene expression and is involved
CC in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000111; ABB50147.1; -; Genomic_DNA.
DR RefSeq; WP_011376638.1; NC_007577.1.
DR AlphaFoldDB; Q31AE8; -.
DR SMR; Q31AE8; -.
DR STRING; 74546.PMT9312_1088; -.
DR EnsemblBacteria; ABB50147; ABB50147; PMT9312_1088.
DR KEGG; pmi:PMT9312_1088; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_723030_0_0_3; -.
DR OMA; AHYGQIW; -.
DR OrthoDB; 1755994at2; -.
DR Proteomes; UP000002715; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_01837; Kinase_SasA; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011649; KaiB_domain.
DR InterPro; IPR023527; Kinase_SasA.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF07689; KaiB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM01248; KaiB; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Kinase; Phosphoprotein; Transferase;
KW Two-component regulatory system.
FT CHAIN 1..372
FT /note="Adaptive-response sensory-kinase SasA"
FT /id="PRO_1000088444"
FT DOMAIN 147..360
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT MOD_RES 150
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ SEQUENCE 372 AA; 42480 MW; 547B9ACC97A08509 CRC64;
MNDKKELKLI LVAARNQLSS SDIKSLIAYL ESDDCNFEIS LQISEPTEQP ELLELHRLVA
IPALIKVSPA PKQIFAGSNI FSQLQKWLPR WNQEGLTKNL GINLQPSKID SIRTQKEYLL
EDELLVLRQE NETLTKRIES QERLLRMVAH ELRTPLTAAT LAVQSQKLGQ IDIAKLQEVI
KRRLEEIELL SQDLLEVGTT KWEALFNPQK IDLGNISAEA ILELEKFWRL RDIEIDTDIP
SDLPSVFADQ RRMRQVFLNL IENAIKFSKD YGSIKITMIH KTNQWVEITI CDKGAGIPLN
EQKRIFLDRV RLPQTSEGTS GFGIGLSVCR RIVQVHGGRI WVVSEIGVGS CFHFTVPVWQ
GQNKEQHYLT KG