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SASA_PROMS
ID   SASA_PROMS              Reviewed;         372 AA.
AC   A2BRQ6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE            EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE   AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN   Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=A9601_11831;
OS   Prochlorococcus marinus (strain AS9601).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=146891;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AS9601;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: May be involved in signal transduction. Participates in the
CC       KaiABC clock protein complex, which constitutes the main circadian
CC       regulator in cyanobacteria, via its interaction with KaiC. Required for
CC       robustness of the circadian rhythm of gene expression and is involved
CC       in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC   -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC       core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC       dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR   EMBL; CP000551; ABM70467.1; -; Genomic_DNA.
DR   RefSeq; WP_011818614.1; NC_008816.1.
DR   AlphaFoldDB; A2BRQ6; -.
DR   SMR; A2BRQ6; -.
DR   STRING; 146891.A9601_11831; -.
DR   EnsemblBacteria; ABM70467; ABM70467; A9601_11831.
DR   KEGG; pmb:A9601_11831; -.
DR   eggNOG; COG2205; Bacteria.
DR   HOGENOM; CLU_723030_0_0_3; -.
DR   OMA; AHYGQIW; -.
DR   OrthoDB; 1755994at2; -.
DR   Proteomes; UP000002590; Chromosome.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_01837; Kinase_SasA; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR011649; KaiB_domain.
DR   InterPro; IPR023527; Kinase_SasA.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF07689; KaiB; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM01248; KaiB; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Kinase; Phosphoprotein; Transferase;
KW   Two-component regulatory system.
FT   CHAIN           1..372
FT                   /note="Adaptive-response sensory-kinase SasA"
FT                   /id="PRO_1000088445"
FT   DOMAIN          147..360
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT   MOD_RES         150
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ   SEQUENCE   372 AA;  42366 MW;  316D659DD12339B1 CRC64;
     MNDKKELKLI LVAARNQLSS NDIKCLIAYL ESDDCEFETS LQISEPKEQP ELLELHRLVA
     IPALIKVSPA PKQIFAGSNI FSQLQKWLPR WSQEGLTKNL GINLQPSKID STRTQKEFLL
     EDELLVLRQE NETLTKRIES QERLLRMVAH ELRTPLTAAT LAVQSQKLGQ IDISKLQEVI
     KRRLEEIELL SQDLLEVGTT KWEALFNPQK IDLGNISAEV ILELEKFWRI RNIEIDTDIP
     SDLPSVFADQ RRMRQVFLNL IENAIKFSKD SGSIKITMIH KTNQWVEITI CDKGAGIPLS
     EQKRIFLDRV RLPQTSEGTS GFGIGLSVCR RIVQVHGGRI WVVSEVGVGS CFHFTVPVWQ
     GQNKEQQNLT KG
 
 
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