SASA_PROMS
ID SASA_PROMS Reviewed; 372 AA.
AC A2BRQ6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=A9601_11831;
OS Prochlorococcus marinus (strain AS9601).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=146891;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS9601;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: May be involved in signal transduction. Participates in the
CC KaiABC clock protein complex, which constitutes the main circadian
CC regulator in cyanobacteria, via its interaction with KaiC. Required for
CC robustness of the circadian rhythm of gene expression and is involved
CC in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR EMBL; CP000551; ABM70467.1; -; Genomic_DNA.
DR RefSeq; WP_011818614.1; NC_008816.1.
DR AlphaFoldDB; A2BRQ6; -.
DR SMR; A2BRQ6; -.
DR STRING; 146891.A9601_11831; -.
DR EnsemblBacteria; ABM70467; ABM70467; A9601_11831.
DR KEGG; pmb:A9601_11831; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_723030_0_0_3; -.
DR OMA; AHYGQIW; -.
DR OrthoDB; 1755994at2; -.
DR Proteomes; UP000002590; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_01837; Kinase_SasA; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011649; KaiB_domain.
DR InterPro; IPR023527; Kinase_SasA.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF07689; KaiB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM01248; KaiB; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Kinase; Phosphoprotein; Transferase;
KW Two-component regulatory system.
FT CHAIN 1..372
FT /note="Adaptive-response sensory-kinase SasA"
FT /id="PRO_1000088445"
FT DOMAIN 147..360
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT MOD_RES 150
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ SEQUENCE 372 AA; 42366 MW; 316D659DD12339B1 CRC64;
MNDKKELKLI LVAARNQLSS NDIKCLIAYL ESDDCEFETS LQISEPKEQP ELLELHRLVA
IPALIKVSPA PKQIFAGSNI FSQLQKWLPR WSQEGLTKNL GINLQPSKID STRTQKEFLL
EDELLVLRQE NETLTKRIES QERLLRMVAH ELRTPLTAAT LAVQSQKLGQ IDISKLQEVI
KRRLEEIELL SQDLLEVGTT KWEALFNPQK IDLGNISAEV ILELEKFWRI RNIEIDTDIP
SDLPSVFADQ RRMRQVFLNL IENAIKFSKD SGSIKITMIH KTNQWVEITI CDKGAGIPLS
EQKRIFLDRV RLPQTSEGTS GFGIGLSVCR RIVQVHGGRI WVVSEVGVGS CFHFTVPVWQ
GQNKEQQNLT KG