SASA_SYNS9
ID SASA_SYNS9 Reviewed; 383 AA.
AC Q3AYV8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837};
GN OrderedLocusNames=Syncc9902_0751;
OS Synechococcus sp. (strain CC9902).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=316279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC9902;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F.,
RA Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Synechococcus sp. CC9902.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in signal transduction. Participates in the
CC KaiABC clock protein complex, which constitutes the main circadian
CC regulator in cyanobacteria, via its interaction with KaiC. Required for
CC robustness of the circadian rhythm of gene expression and is involved
CC in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR EMBL; CP000097; ABB25719.1; -; Genomic_DNA.
DR RefSeq; WP_011359559.1; NC_007513.1.
DR AlphaFoldDB; Q3AYV8; -.
DR SMR; Q3AYV8; -.
DR STRING; 316279.Syncc9902_0751; -.
DR PRIDE; Q3AYV8; -.
DR EnsemblBacteria; ABB25719; ABB25719; Syncc9902_0751.
DR KEGG; sye:Syncc9902_0751; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_723030_0_0_3; -.
DR OMA; AHYGQIW; -.
DR OrthoDB; 1755994at2; -.
DR Proteomes; UP000002712; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd02978; KaiB_like; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_01837; Kinase_SasA; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011649; KaiB_domain.
DR InterPro; IPR023527; Kinase_SasA.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF07689; KaiB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM01248; KaiB; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Kinase; Phosphoprotein; Reference proteome;
KW Transferase; Two-component regulatory system.
FT CHAIN 1..383
FT /note="Adaptive-response sensory-kinase SasA"
FT /id="PRO_1000088449"
FT DOMAIN 152..365
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT MOD_RES 155
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ SEQUENCE 383 AA; 43282 MW; 1D188DE8AAD2EFF0 CRC64;
MVDDGPKGRQ QLKLLLVAAR HQLSGQDLRG LVHYLEREDL GFEVTLQVAD PTQQPELLEL
HRLVVTPALI KLQPSPKQVF AGSNILQQLK GWVPRWKQDG VVSGLGLSLR PTELDGSRTQ
KELQLEDQLL VLRQENETLI DRIHAQERLL RMVAHELRTP LTAAALALQS QRLGQIDMDR
FQDVVTRRLE EMEALSKDLL EVGTTRWETL FNPQRLDLAS VSAEVILELE KLWLGRNVEI
RTDIPSDLPK VFADQRRMRQ VLLNLLENAL KYTGNGGHIA LSMLHRTNQW VEVSVCDSGP
GIPNEEQQRI FLDRVRLPQT SDRTTGFGVG LSVCRRIVEV HGGRIWVVSE PEEGACFTFT
VPIWQGQGQE WGQAVLTEGQ ADP