ID   SASA_TRIV2              Reviewed;         401 AA.
AC   Q3M8A7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Adaptive-response sensory-kinase SasA {ECO:0000255|HAMAP-Rule:MF_01837};
DE            EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_01837};
DE   AltName: Full=Synechococcus adaptive sensor protein A {ECO:0000255|HAMAP-Rule:MF_01837};
GN   Name=sasA {ECO:0000255|HAMAP-Rule:MF_01837}; OrderedLocusNames=Ava_3171;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- FUNCTION: May be involved in signal transduction. Participates in the
CC       KaiABC clock protein complex, which constitutes the main circadian
CC       regulator in cyanobacteria, via its interaction with KaiC. Required for
CC       robustness of the circadian rhythm of gene expression and is involved
CC       in clock outputs. {ECO:0000255|HAMAP-Rule:MF_01837}.
CC   -!- SUBUNIT: Interacts with KaiC. Participates in the KaiABC complex, whose
CC       core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA
CC       dimers. {ECO:0000255|HAMAP-Rule:MF_01837}.
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DR   EMBL; CP000117; ABA22779.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3M8A7; -.
DR   SMR; Q3M8A7; -.
DR   STRING; 240292.Ava_3171; -.
DR   EnsemblBacteria; ABA22779; ABA22779; Ava_3171.
DR   KEGG; ava:Ava_3171; -.
DR   eggNOG; COG2205; Bacteria.
DR   HOGENOM; CLU_723030_0_0_3; -.
DR   OMA; AHYGQIW; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd02978; KaiB_like; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_01837; Kinase_SasA; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR011649; KaiB_domain.
DR   InterPro; IPR023527; Kinase_SasA.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF07689; KaiB; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM01248; KaiB; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Kinase; Phosphoprotein; Transferase;
KW   Two-component regulatory system.
FT   CHAIN           1..401
FT                   /note="Adaptive-response sensory-kinase SasA"
FT                   /id="PRO_1000088439"
FT   DOMAIN          175..400
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
FT   MOD_RES         178
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01837"
SQ   SEQUENCE   401 AA;  45608 MW;  F5F2D27B5F8A9325 CRC64;
     MLKHDSMQVS QDQPIYSEAP LQLLLFVDGR PKSKQQVQRI RAYLKDLQAE YNFELQIIDV
     GQQPYLAEHF KLVATPALIK IHPEPRQILA GSNIITQLKN LWPRWQAAVD TYVKLQEDLQ
     ERVDDNGRVA QPTSTINSVA VSAELLRLSD EIFNLKQEKE KLLEQLQFKD RVIAMLVHDL
     RNPLTAAAIA IETLQSNYNP DIGQFQRLKP ALVVNLLRQA RTQAKTIDKM IADLLQVGRG
     TDTELIIIPQ KTEIGLLCLE VLGELRDRYT TKAQKVETDI PQDLPCVYAD PERIRQVLIN
     LLDNAIKYTP EGGTISIAGL HRTTQKVQFS IGDTGPGIPT DNRERIFENH YRLERDEAKE
     GYGIGLSLCQ RIIRAHYGQI WVDSNPHGGA WFHFTLPVYP S