SASH3_BOVIN
ID SASH3_BOVIN Reviewed; 380 AA.
AC A0JN71;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=SAM and SH3 domain-containing protein 3;
GN Name=SASH3 {ECO:0000250|UniProtKB:Q8K352};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI26546.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford {ECO:0000312|EMBL:AAI26546.1};
RC TISSUE=Thymus {ECO:0000312|EMBL:AAI26546.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a signaling adapter protein in lymphocytes.
CC {ECO:0000250|UniProtKB:Q8K352}.
CC -!- SIMILARITY: Belongs to the SASH family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI26546.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AAFC03003066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126545; AAI26546.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001071466.1; NM_001077998.2.
DR RefSeq; XP_010819700.1; XM_010821398.2.
DR AlphaFoldDB; A0JN71; -.
DR SMR; A0JN71; -.
DR STRING; 9913.ENSBTAP00000002645; -.
DR PaxDb; A0JN71; -.
DR PRIDE; A0JN71; -.
DR Ensembl; ENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041.
DR GeneID; 534137; -.
DR KEGG; bta:534137; -.
DR CTD; 54440; -.
DR VEuPathDB; HostDB:ENSBTAG00000002041; -.
DR VGNC; VGNC:34294; SASH3.
DR eggNOG; KOG4384; Eukaryota.
DR GeneTree; ENSGT00940000160111; -.
DR HOGENOM; CLU_027875_0_0_1; -.
DR InParanoid; A0JN71; -.
DR OMA; DKEPTQK; -.
DR OrthoDB; 278880at2759; -.
DR TreeFam; TF350709; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000002041; Expressed in thymus and 99 other tissues.
DR ExpressionAtlas; A0JN71; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0043367; P:CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0002821; P:positive regulation of adaptive immune response; IBA:GO_Central.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IBA:GO_Central.
DR GO; GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IBA:GO_Central.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; IEA:Ensembl.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR CDD; cd11968; SH3_SASH3; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR021090; rSAM/SH3_domain-containing.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR035722; SASH3.
DR InterPro; IPR035721; SASH3_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12301:SF5; PTHR12301:SF5; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF12485; SLY; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; SH3 domain.
FT CHAIN 1..380
FT /note="SAM and SH3 domain-containing protein 3"
FT /id="PRO_0000331222"
FT DOMAIN 173..234
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 252..316
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 1..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 27
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 61
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 103
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 112
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 318
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75995"
FT CONFLICT 318
FT /note="T -> S (in Ref. 1; AAFC03003066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 41566 MW; 7CD75BE4EDFB7352 CRC64;
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDESSVP
TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM GDTLEEGSAS PTSPDCSLDS
PGPEKMALAF SEQEERELPA LSRQASTGSE LCSPSPGSGN LGEESTAPQY TGPFCGRARV
HTDFTPSPYD RDSLKLQKGD VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA
RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG CFEGSESGRD
EAELAGTEEQ LHGLSLSGAP
