SAST_SANAL
ID SAST_SANAL Reviewed; 559 AA.
AC F6M8H4;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Probable sesquiterpene synthase;
DE Short=SaSTPS;
DE EC=4.2.3.-;
GN Name=SesquiTPS1;
OS Santalum album (White sandalwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC Santalales; Santalaceae; Santalum.
OX NCBI_TaxID=35974;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=21454632; DOI=10.1074/jbc.m111.231787;
RA Jones C.G., Moniodis J., Zulak K.G., Scaffidi A., Plummer J.A.,
RA Ghisalberti E.L., Barbour E.L., Bohlmann J.;
RT "Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both
RT the terpene synthase (TPS)-a and TPS-b Subfamilies, including santalene
RT synthases.";
RL J. Biol. Chem. 286:17445-17454(2011).
CC -!- FUNCTION: Sesquiterpene synthase. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the terpene synthase family. Tpsa subfamily.
CC {ECO:0000305}.
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DR EMBL; JF746807; AEF32534.1; -; Genomic_DNA.
DR AlphaFoldDB; F6M8H4; -.
DR SMR; F6M8H4; -.
DR PRIDE; F6M8H4; -.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR Gene3D; 1.10.600.10; -; 1.
DR Gene3D; 1.50.10.130; -; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR InterPro; IPR001906; Terpene_synth_N.
DR InterPro; IPR036965; Terpene_synth_N_sf.
DR InterPro; IPR005630; Terpene_synthase_metal-bd.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR Pfam; PF01397; Terpene_synth; 1.
DR Pfam; PF03936; Terpene_synth_C; 1.
DR SUPFAM; SSF48239; SSF48239; 1.
DR SUPFAM; SSF48576; SSF48576; 1.
PE 3: Inferred from homology;
KW Lyase; Magnesium; Manganese; Metal-binding.
FT CHAIN 1..559
FT /note="Probable sesquiterpene synthase"
FT /id="PRO_0000419325"
FT MOTIF 312..316
FT /note="DDXXD motif"
FT BINDING 312
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 312
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 316
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 316
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 464
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 559 AA; 65674 MW; 7B05A5B40FC7BEEF CRC64;
MENQKMPISS VPILKDLSRP IANFPPSIWG DRFINYTCQD ENERAQKERQ VEELKEQVRR
ELAATVDKPL QQQNIIDATQ RLGIAYHFEN EIEESLEHIY LHTYVENTCF EGSDDLYSVA
LWFRLLRQNG YRVSCDVFNK FRDNEGNFKN NLMEDAKGLL ELYEATHLSV HGEEMLDDAL
EFTKTRLESV VSHLNYPLAE QVRHALYQPL HKGLPRLEAV YFFRIYEAHA SHNKALLKLA
KLDFNLLQSF HKKELSDIAR WWKSLDFATK VPFARDRLVE GYFWVLGVYF EPQYSLARKI
IIKVFTMIST IDDIYDAYGT VDELKLFTEA IRRWDVGSLD QLPEYMKPCY KSILEVYNEI
EEEMDNQGSL FRMHYAKEVM KKLVEGYMDE AKWCHEKYVP TFEEYMSVAL VTSGYTFLTT
MSYLGMGEIA SKEAFDWLFS HPPVIEASES VGRLMDDMRS HKFERERGHV ASGIECYMKQ
YSVTEEEAYD EFCKRLVKAW KDINEECLRP YHVPKPLLMR ILNLTRVIDV IYKNEDGYTH
VKKAMKDNIA SLLIDPMIV
