ID   SAT_ENTHI               Reviewed;         423 AA.
AC   O76156;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Sulfate adenylyltransferase;
DE            EC=2.7.7.4;
DE   AltName: Full=ATP-sulfurylase;
DE   AltName: Full=Sulfate adenylate transferase;
DE            Short=SAT;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RA   Nozaki T.;
RT   "Entamoeba histolytica ATP sulfurylase.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H(+) + sulfate = adenosine 5'-phosphosulfate +
CC         diphosphate; Xref=Rhea:RHEA:18133, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16189, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58243; EC=2.7.7.4;
CC   -!- PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from
CC       sulfate: step 1/3.
CC   -!- SIMILARITY: Belongs to the sulfate adenylyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AB013399; BAA32829.1; -; Genomic_DNA.
DR   AlphaFoldDB; O76156; -.
DR   SMR; O76156; -.
DR   STRING; 5759.rna_EHI_197160-1; -.
DR   PRIDE; O76156; -.
DR   VEuPathDB; AmoebaDB:EHI5A_152340; -.
DR   VEuPathDB; AmoebaDB:EHI7A_191560; -.
DR   VEuPathDB; AmoebaDB:EHI8A_232720; -.
DR   VEuPathDB; AmoebaDB:EHI_197160; -.
DR   VEuPathDB; AmoebaDB:KM1_292970; -.
DR   eggNOG; KOG0636; Eukaryota.
DR   OMA; LQHMIIR; -.
DR   UniPathway; UPA00140; UER00204.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR   CDD; cd00517; ATPS; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00066; Sulf_adenylyltr; 1.
DR   InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR020792; SO4_adenylyltransferase_pro.
DR   InterPro; IPR024951; Sulfurylase_cat_dom.
DR   InterPro; IPR002650; Sulphate_adenylyltransferase.
DR   Pfam; PF01747; ATP-sulfurylase; 1.
DR   Pfam; PF14306; PUA_2; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00339; sopT; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Cysteine biosynthesis;
KW   Methionine biosynthesis; Nucleotide-binding; Nucleotidyltransferase;
KW   Transferase.
FT   CHAIN           1..423
FT                   /note="Sulfate adenylyltransferase"
FT                   /id="PRO_0000105955"
SQ   SEQUENCE   423 AA;  47928 MW;  5E6D30DF1C63F185 CRC64;
     MSIQENLNNL IKPHGGKLIK TLKYGAERDE CIKEAKSLPK IDISSREFGD LVMMGIGGFS
     PLNGFMKKED WFSVCKNFTL ADGTFWPIPI TMSVSEEEAK KLKRGQKVAL KYNKDINDIS
     GTIEIDQVYE MTKKDKEMEC KDIFTTTDSD HPGVKKVMEQ KPFNVAGKVT TLSEGEFPIK
     YKGIYMTPEE SRLNFAKKGW KTIAALQLRN PMHRSHEFLA KIAVEVCDGV FIHSLVGNLK
     PGDIPAEVRV KCIDALVDKY FVKKNVLQGG YPLDMRYGGP REALLHATFR QNYGCTHMII
     GRDHAGVGDY YGPFDAQKIF DKIPYNADPK KRLLTQPMKI DWTFYCHKCD GMASLRTCPH
     TKKDRVIVSG TMVRKMLSEG KTLPDHFGRA ESLKILADYY QHLDKSKKVT IKLQKFATGD
     AMK