SAU19_ARATH
ID SAU19_ARATH Reviewed; 90 AA.
AC Q9FJG1;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Auxin-responsive protein SAUR19 {ECO:0000305};
DE AltName: Full=Protein SMALL AUXIN UP RNA 19 {ECO:0000303|PubMed:12036261};
GN Name=SAUR19 {ECO:0000303|PubMed:12036261};
GN OrderedLocusNames=At5g18010 {ECO:0000312|Araport:AT5G18010};
GN ORFNames=MCM23.9 {ECO:0000312|EMBL:BAB08400.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12036261; DOI=10.1023/a:1015207114117;
RA Hagen G., Guilfoyle T.J.;
RT "Auxin-responsive gene expression: genes, promoters and regulatory
RT factors.";
RL Plant Mol. Biol. 49:373-385(2002).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION BY AUXIN.
RX PubMed=22348445; DOI=10.1111/j.1365-313x.2012.04946.x;
RA Spartz A.K., Lee S.H., Wenger J.P., Gonzalez N., Itoh H., Inze D.,
RA Peer W.A., Murphy A.S., Overvoorde P.J., Gray W.M.;
RT "The SAUR19 subfamily of SMALL AUXIN UP RNA genes promote cell expansion.";
RL Plant J. 70:978-990(2012).
RN [7]
RP FUNCTION, AND INTERACTION WITH PP2C67/PP2C-D1; PP2C64/PP2C-D5 AND
RP PP2C46/PP2C-D6.
RC STRAIN=cv. Columbia;
RX PubMed=24858935; DOI=10.1105/tpc.114.126037;
RA Spartz A.K., Ren H., Park M.Y., Grandt K.N., Lee S.H., Murphy A.S.,
RA Sussman M.R., Overvoorde P.J., Gray W.M.;
RT "SAUR inhibition of PP2C-D phosphatases activates plasma membrane H+-
RT ATPases to promote cell expansion in Arabidopsis.";
RL Plant Cell 26:2129-2142(2014).
RN [8]
RP FUNCTION, AND INDUCTION BY AUXIN.
RX PubMed=27999086; DOI=10.1104/pp.16.01514;
RA Spartz A.K., Lor V.S., Ren H., Olszewski N.E., Miller N.D., Wu G.,
RA Spalding E.P., Gray W.M.;
RT "Constitutive expression of Arabidopsis SMALL AUXIN UP RNA19 (SAUR19) in
RT tomato confers auxin-independent hypocotyl elongation.";
RL Plant Physiol. 173:1453-1462(2017).
RN [9]
RP INDUCTION BY BRASSINOLIDE.
RC STRAIN=cv. Columbia;
RX PubMed=30649552; DOI=10.1093/pcp/pcz005;
RA Minami A., Takahashi K., Inoue S.I., Tada Y., Kinoshita T.;
RT "Brassinosteroid induces phosphorylation of the plasma membrane H+-ATPase
RT during hypocotyl elongation in Arabidopsis thaliana.";
RL Plant Cell Physiol. 60:935-944(2019).
CC -!- FUNCTION: Provide a mechanistic link between auxin and plasma membrane
CC H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), and triggers PM
CC H(+)-ATPases activity by promoting phosphorylation of their C-terminal
CC autoinhibitory domain as a result of PP2C-D subfamily of type 2C
CC phosphatases inhibition, thus leading to the acidification of the
CC apoplast and the facilitation of solutes and water uptake to drive cell
CC expansion (PubMed:24858935, PubMed:27999086). Prevents the apical hook
CC maintenance of etiolated seedlings (PubMed:24858935). Functions as
CC positive effectors of cell expansion through modulation of auxin
CC transport (PubMed:22348445, PubMed:27999086).
CC {ECO:0000269|PubMed:22348445, ECO:0000269|PubMed:24858935,
CC ECO:0000269|PubMed:27999086}.
CC -!- SUBUNIT: Interacts with and inhibits PP2C-D subfamily of type 2C
CC phosphatases such as PP2C67/PP2C-D1, PP2C64/PP2C-D5 and PP2C46/PP2C-D6.
CC {ECO:0000269|PubMed:24858935}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22348445};
CC Peripheral membrane protein {ECO:0000269|PubMed:22348445}.
CC -!- INDUCTION: By auxin (PubMed:22348445, PubMed:27999086). Triggered by
CC brassinosteroids, including brassinolide (BL) (PubMed:30649552).
CC {ECO:0000269|PubMed:22348445, ECO:0000269|PubMed:27999086,
CC ECO:0000269|PubMed:30649552}.
CC -!- MISCELLANEOUS: Seedlings over-expressing SAUR19 display auxin-related
CC phenotypes. These phenotypes include increased cell expansion,
CC increased hypocotyl and leaf size, defective apical hook maintenance,
CC altered tropic responses and increased basipetal auxin transport in
CC hypocotyls. {ECO:0000269|PubMed:22348445}.
CC -!- SIMILARITY: Belongs to the ARG7 family. {ECO:0000305}.
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DR EMBL; AB015473; BAB08400.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92495.1; -; Genomic_DNA.
DR EMBL; BT010805; AAR24172.1; -; mRNA.
DR EMBL; BT011287; AAR92323.1; -; mRNA.
DR EMBL; AK229287; BAF01150.1; -; mRNA.
DR RefSeq; NP_197302.1; NM_121806.5.
DR AlphaFoldDB; Q9FJG1; -.
DR IntAct; Q9FJG1; 1.
DR STRING; 3702.AT5G18010.1; -.
DR PaxDb; Q9FJG1; -.
DR PRIDE; Q9FJG1; -.
DR EnsemblPlants; AT5G18010.1; AT5G18010.1; AT5G18010.
DR GeneID; 831668; -.
DR Gramene; AT5G18010.1; AT5G18010.1; AT5G18010.
DR KEGG; ath:AT5G18010; -.
DR Araport; AT5G18010; -.
DR TAIR; locus:2161538; AT5G18010.
DR eggNOG; ENOG502STBD; Eukaryota.
DR HOGENOM; CLU_098106_3_0_1; -.
DR InParanoid; Q9FJG1; -.
DR OMA; TILCTED; -.
DR OrthoDB; 1546561at2759; -.
DR PhylomeDB; Q9FJG1; -.
DR PRO; PR:Q9FJG1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJG1; baseline and differential.
DR GO; GO:0019897; C:extrinsic component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
DR GO; GO:2000012; P:regulation of auxin polar transport; IMP:UniProtKB.
DR GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR GO; GO:0009741; P:response to brassinosteroid; IEP:UniProtKB.
DR InterPro; IPR003676; SAUR_fam.
DR PANTHER; PTHR31929; PTHR31929; 1.
DR Pfam; PF02519; Auxin_inducible; 1.
PE 1: Evidence at protein level;
KW Auxin signaling pathway; Cell membrane; Developmental protein;
KW Growth regulation; Membrane; Reference proteome.
FT CHAIN 1..90
FT /note="Auxin-responsive protein SAUR19"
FT /id="PRO_0000433061"
SQ SEQUENCE 90 AA; 9738 MW; EB0449A28642A191 CRC64;
MAFVRSLLGA KKILSRSTAA GSAAPKGFLA VYVGESQKKR YLVPLSYLSQ PSFQALLSKS
EEEFGFAHPM GGLTIPCPED TFINVTSRLQ
