SAU50_ARATH
ID SAU50_ARATH Reviewed; 107 AA.
AC O65695; Q94B76;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Auxin-responsive protein SAUR50 {ECO:0000303|PubMed:12036261};
DE AltName: Full=Protein SMALL AUXIN UP-REGULATED RNA 50 {ECO:0000303|PubMed:12036261};
GN Name=SAUR50 {ECO:0000303|PubMed:12036261};
GN OrderedLocusNames=At4g34760 {ECO:0000312|Araport:AT4G34760};
GN ORFNames=T4L20.340 {ECO:0000312|EMBL:CAA18855.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12036261; DOI=10.1023/a:1015207114117;
RA Hagen G., Guilfoyle T.J.;
RT "Auxin-responsive gene expression: genes, promoters and regulatory
RT factors.";
RL Plant Mol. Biol. 49:373-385(2002).
RN [6]
RP INDUCTION BY AUXIN.
RX PubMed=16901781; DOI=10.1016/j.cell.2006.05.050;
RA Nemhauser J.L., Hong F., Chory J.;
RT "Different plant hormones regulate similar processes through largely
RT nonoverlapping transcriptional responses.";
RL Cell 126:467-475(2006).
RN [7]
RP INDUCTION BY AUXIN; ARF7 AND TROPIC STIMULUS.
RX PubMed=16371470; DOI=10.1073/pnas.0507127103;
RA Esmon C.A., Tinsley A.G., Ljung K., Sandberg G., Hearne L.B., Liscum E.;
RT "A gradient of auxin and auxin-dependent transcription precedes tropic
RT growth responses.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:236-241(2006).
RN [8]
RP INDUCTION BY HORMONES, AND INTERACTION WITH BZR1.
RX PubMed=23020777; DOI=10.1146/annurev-genet-102209-163450;
RA Wang Z.Y., Bai M.Y., Oh E., Zhu J.Y.;
RT "Brassinosteroid signaling network and regulation of photomorphogenesis.";
RL Annu. Rev. Genet. 46:701-724(2012).
RN [9]
RP FUNCTION.
RX PubMed=25983207; DOI=10.1016/j.molp.2015.05.003;
RA Ren H., Gray W.M.;
RT "SAUR proteins as effectors of hormonal and environmental signals in plant
RT growth.";
RL Mol. Plant 8:1153-1164(2015).
RN [10]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION BY AUXIN;
RP BRASSINOSTEROIDS AND ZEATIN, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=29258424; DOI=10.1186/s12870-017-1210-4;
RA van Mourik H., van Dijk A.D.J., Stortenbeker N., Angenent G.C., Bemer M.;
RT "Divergent regulation of Arabidopsis SAUR genes: a focus on the SAUR10-
RT clade.";
RL BMC Plant Biol. 17:245-245(2017).
CC -!- FUNCTION: Provide a mechanistic link between auxin and plasma membrane
CC H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), and triggers PM
CC H(+)-ATPases activity by promoting phosphorylation of their C-terminal
CC autoinhibitory domain as a result of PP2C-D subfamily of type 2C
CC phosphatases inhibition, thus leading to the acidification of the
CC apoplast and the facilitation of solutes and water uptake to drive cell
CC expansion (By similarity). Triggers plant growth probably by promoting
CC cell elongation (By similarity). Regulates branch angles and bending
CC (By similarity). Effector of hormonal and environmental signals in
CC plant growth (Probable). {ECO:0000250|UniProtKB:O65648,
CC ECO:0000250|UniProtKB:Q9SI60, ECO:0000305|PubMed:25983207}.
CC -!- SUBUNIT: Interacts with BZR1. {ECO:0000269|PubMed:23020777}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9FJG1};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q9FJG1}.
CC -!- TISSUE SPECIFICITY: Expressed in cotyledons, leaves, flowers and
CC siliques. {ECO:0000269|PubMed:29258424}.
CC -!- DEVELOPMENTAL STAGE: In flowers, present in stamen, petals and stigma.
CC {ECO:0000269|PubMed:29258424}.
CC -!- INDUCTION: Up-regulated by brassinosteroids and gibberellins
CC (PubMed:23020777, PubMed:29258424). Up-regulated by auxin
CC (PubMed:16901781, PubMed:16371470, PubMed:29258424). Up-regulated by
CC phototropism and gravitropism in the region of the hypocotyl farthest
CC form the incident stimulation (PubMed:16371470). Transcriptionally
CC regulated by ARF7 (PubMed:16371470). Down-regulated by abscisic acid
CC and methyl jasmonate (PubMed:23020777). Induced by zeatin
CC (PubMed:29258424). {ECO:0000269|PubMed:16371470,
CC ECO:0000269|PubMed:16901781, ECO:0000269|PubMed:23020777,
CC ECO:0000269|PubMed:29258424}.
CC -!- SIMILARITY: Belongs to the ARG7 family. {ECO:0000305}.
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DR EMBL; AL023094; CAA18855.1; -; Genomic_DNA.
DR EMBL; AL161586; CAB80193.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86420.1; -; Genomic_DNA.
DR EMBL; AY042802; AAK68742.2; -; mRNA.
DR EMBL; BT000358; AAN15677.1; -; mRNA.
DR EMBL; AY084348; AAM60931.1; -; mRNA.
DR PIR; T05296; T05296.
DR RefSeq; NP_195202.1; NM_119642.4.
DR AlphaFoldDB; O65695; -.
DR SMR; O65695; -.
DR STRING; 3702.AT4G34760.1; -.
DR PaxDb; O65695; -.
DR PRIDE; O65695; -.
DR EnsemblPlants; AT4G34760.1; AT4G34760.1; AT4G34760.
DR GeneID; 829628; -.
DR Gramene; AT4G34760.1; AT4G34760.1; AT4G34760.
DR KEGG; ath:AT4G34760; -.
DR Araport; AT4G34760; -.
DR TAIR; locus:2139589; AT4G34760.
DR eggNOG; ENOG502RZ3M; Eukaryota.
DR HOGENOM; CLU_098106_2_3_1; -.
DR InParanoid; O65695; -.
DR OMA; KSNKMPQ; -.
DR OrthoDB; 1463651at2759; -.
DR PhylomeDB; O65695; -.
DR PRO; PR:O65695; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O65695; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR GO; GO:0009741; P:response to brassinosteroid; IEP:UniProtKB.
DR InterPro; IPR003676; SAUR_fam.
DR PANTHER; PTHR31374; PTHR31374; 1.
DR Pfam; PF02519; Auxin_inducible; 1.
PE 1: Evidence at protein level;
KW Auxin signaling pathway; Cell membrane; Developmental protein;
KW Growth regulation; Membrane; Reference proteome.
FT CHAIN 1..107
FT /note="Auxin-responsive protein SAUR50"
FT /id="PRO_0000437983"
FT CONFLICT 17
FT /note="K -> E (in Ref. 3; AAK68742/AAN15677)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 107 AA; 12139 MW; 49F5942F79CCA7F7 CRC64;
MAIMKKTSKL TQTAMLKQIL KRCSSLGKKN GGGYDEDCLP LDVPKGHFPV YVGENRSRYI
VPISFLTHPE FQSLLQRAEE EFGFDHDMGL TIPCDELVFQ TLTSMIR
