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SAU76_ARATH
ID   SAU76_ARATH             Reviewed;         127 AA.
AC   Q29PU2; Q8LDL3;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Auxin-responsive protein SAUR76 {ECO:0000305};
DE   AltName: Full=Protein SMALL AUXIN UP RNA 76 {ECO:0000303|PubMed:24312429};
GN   Name=SAUR76 {ECO:0000303|PubMed:24312429};
GN   OrderedLocusNames=At5g20820 {ECO:0000312|Araport:AT5G20820};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INDUCTION BY ETHYLENE.
RX   PubMed=23134674; DOI=10.1186/1471-2229-12-208;
RA   Markakis M.N., De Cnodder T., Lewandowski M., Simon D., Boron A.,
RA   Balcerowicz D., Doubbo T., Taconnat L., Renou J.P., Hoefte H.,
RA   Verbelen J.P., Vissenberg K.;
RT   "Identification of genes involved in the ACC-mediated control of root cell
RT   elongation in Arabidopsis thaliana.";
RL   BMC Plant Biol. 12:208-208(2012).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=24312429; DOI=10.1371/journal.pone.0082596;
RA   Markakis M.N., Boron A.K., Van Loock B., Saini K., Cirera S.,
RA   Verbelen J.P., Vissenberg K.;
RT   "Characterization of a small auxin-up RNA (SAUR)-like gene involved in
RT   Arabidopsis thaliana development.";
RL   PLoS ONE 8:E82596-E82596(2013).
RN   [7]
RP   FUNCTION, AND RETRACTED PAPER.
RX   PubMed=26207341; DOI=10.1038/srep12477;
RA   Li Z.G., Chen H.W., Li Q.T., Tao J.J., Bian X.H., Ma B., Zhang W.K.,
RA   Chen S.Y., Zhang J.S.;
RT   "Three SAUR proteins SAUR76, SAUR77 and SAUR78 promote plant growth in
RT   Arabidopsis.";
RL   Sci. Rep. 5:12477-12477(2015).
RN   [8]
RP   RETRACTION NOTICE OF PUBMED:26207341.
RX   PubMed=35105927; DOI=10.1038/s41598-022-06178-8;
RA   Li Z.G., Chen H.W., Li Q.T., Tao J.J., Bian X.H., Ma B., Zhang W.K.,
RA   Chen S.Y., Zhang J.S.;
RL   Sci. Rep. 12:1994-1994(2022).
CC   -!- FUNCTION: May be involved in the regulation of ethylene receptor
CC       signaling. Promotes cell expansion and plant growth (Probable).
CC       Involved in the regulation of cell elongation (PubMed:24312429).
CC       {ECO:0000269|PubMed:24312429, ECO:0000305|PubMed:26207341}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24312429}. Cytoplasm
CC       {ECO:0000269|PubMed:24312429}. Cell membrane
CC       {ECO:0000269|PubMed:24312429}; Peripheral membrane protein
CC       {ECO:0000305|PubMed:24312429}.
CC   -!- TISSUE SPECIFICITY: Expressed in cotyledons, hypocotyls and roots of
CC       young seedlings. Expressed in emerging lateral root, leaves, flowers,
CC       stamens and filaments. {ECO:0000269|PubMed:24312429}.
CC   -!- INDUCTION: Induced by ethylene in roots (PubMed:23134674,
CC       PubMed:24312429). Induced by auxin in roots. Down-regulated by abscisic
CC       acid (ABA) and paclobutrazol (PubMed:24312429).
CC       {ECO:0000269|PubMed:23134674, ECO:0000269|PubMed:24312429}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:24312429}.
CC   -!- MISCELLANEOUS: Plants over-expressing SAUR76 display increased root
CC       growth and reduced number of cells in leaves leading to reduced leaf
CC       area (PubMed:24312429). Plants silencing SAUR76 exhibit increased
CC       sensitivity to ethylene, while plants over-expressing SAUR76 display
CC       reduced ethylene sensitivity. Plants over-expressing SAUR76 exhibit
CC       increased rosette diameters (PubMed:26207341).
CC       {ECO:0000269|PubMed:24312429, ECO:0000269|PubMed:26207341}.
CC   -!- SIMILARITY: Belongs to the ARG7 family. {ECO:0000305}.
CC   -!- CAUTION: The article by Li et al was retracted by the editors after
CC       publication. Concerns were raised regarding a number of figure panels,
CC       such as partial overlap between the panels and duplication of protein
CC       gel analysis. {ECO:0000305|PubMed:35105927}.
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DR   EMBL; AF296832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92893.1; -; Genomic_DNA.
DR   EMBL; BT024814; ABD60697.1; -; mRNA.
DR   EMBL; AY085940; AAM63151.1; -; mRNA.
DR   RefSeq; NP_197582.1; NM_122089.2.
DR   AlphaFoldDB; Q29PU2; -.
DR   STRING; 3702.AT5G20820.1; -.
DR   PaxDb; Q29PU2; -.
DR   PRIDE; Q29PU2; -.
DR   ProteomicsDB; 232841; -.
DR   EnsemblPlants; AT5G20820.1; AT5G20820.1; AT5G20820.
DR   GeneID; 832205; -.
DR   Gramene; AT5G20820.1; AT5G20820.1; AT5G20820.
DR   KEGG; ath:AT5G20820; -.
DR   Araport; AT5G20820; -.
DR   TAIR; locus:2180479; AT5G20820.
DR   eggNOG; ENOG502S116; Eukaryota.
DR   HOGENOM; CLU_098106_6_2_1; -.
DR   InParanoid; Q29PU2; -.
DR   OMA; RPYQVSS; -.
DR   OrthoDB; 1492234at2759; -.
DR   PhylomeDB; Q29PU2; -.
DR   PRO; PR:Q29PU2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q29PU2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0019897; C:extrinsic component of plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
DR   GO; GO:0009733; P:response to auxin; IEA:InterPro.
DR   InterPro; IPR003676; SAUR_fam.
DR   PANTHER; PTHR31374; PTHR31374; 1.
DR   Pfam; PF02519; Auxin_inducible; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Developmental protein;
KW   Ethylene signaling pathway; Growth regulation; Membrane; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..127
FT                   /note="Auxin-responsive protein SAUR76"
FT                   /id="PRO_0000444007"
FT   REGION          20..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        29
FT                   /note="P -> Q (in Ref. 4; AAM63151)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        35
FT                   /note="S -> G (in Ref. 4; AAM63151)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        59
FT                   /note="T -> P (in Ref. 4; AAM63151)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   127 AA;  13981 MW;  27E25FD9D8988FE8 CRC64;
     MAKGGNKLMK LKSVLKKLNS FNTKPNQPPA QTNHSRSSAV SAFPSEDLQT VYVGRTRRTY
     HVSSDVVSHP LFQQLAAVDG GCGSEDGSIS VSCEVVLFEH LLWMLENADA DESRPESVYE
     LVEFYAC
 
 
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