ID   SAUU_CUPNH              Reviewed;         430 AA.
AC   Q0K843;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable sulfoacetate transporter SauU;
GN   Name=sauU; OrderedLocusNames=H16_A2749;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
RN   [2]
RP   FUNCTION, INDUCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=20693281; DOI=10.1074/jbc.m110.127043;
RA   Weinitschke S., Hollemeyer K., Kusian B., Bowien B., Smits T.H., Cook A.M.;
RT   "Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and
RT   sulfoacetaldehyde in Cupriavidus necator H16.";
RL   J. Biol. Chem. 285:35249-35254(2010).
CC   -!- FUNCTION: May transport sulfoacetate into the cell.
CC       {ECO:0000269|PubMed:20693281}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Induced by sulfoacetate. {ECO:0000269|PubMed:20693281}.
CC   -!- DISRUPTION PHENOTYPE: Mutants do not grow with sulfoacetate, but can
CC       use acetate, taurine, isethionate and sulfoacetaldehyde. Mutants are
CC       also unable to induce expression of the sau cluster.
CC       {ECO:0000269|PubMed:20693281}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AM260479; CAJ93828.1; -; Genomic_DNA.
DR   RefSeq; WP_011615811.1; NZ_CP039287.1.
DR   AlphaFoldDB; Q0K843; -.
DR   SMR; Q0K843; -.
DR   STRING; 381666.H16_A2749; -.
DR   EnsemblBacteria; CAJ93828; CAJ93828; H16_A2749.
DR   GeneID; 57644873; -.
DR   KEGG; reh:H16_A2749; -.
DR   PATRIC; fig|381666.6.peg.3145; -.
DR   eggNOG; COG2271; Bacteria.
DR   HOGENOM; CLU_001265_5_1_4; -.
DR   OMA; YNEQSQM; -.
DR   OrthoDB; 1345431at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..430
FT                   /note="Probable sulfoacetate transporter SauU"
FT                   /id="PRO_0000418822"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  46800 MW;  FB328288AC7286FE CRC64;
     MKQRIKTRHM ILGVMCLMYF IAYIDRVNIS VAAPLIREEM GLTTSQLGLV FSAFAYPYAA
     MQILGGWMAD KFGPKKVLIV LSLIWGVATV LTGFAGSVLI LVVLRFVLGI GEGGAFPTAT
     RAFTYWMPVA ERGFAQGITH SFARLGGAIT PPVVLVIVAA AGWREAFIVL GAVSLGWTLL
     YAFFFKDSPD KHSRVTAQEL QEIGYRHGDS RQAAKAATPW RRLFRRMWLV TFVDFCYGWS
     LWVYLTWLPS YLKEARGFDL KQLALFTALP LMAGVVGDTL GGVLSDRIYK RTGNLRLARG
     AVLFVGLAGS LMFIAPMTFT ADAVNAVILL SLSFFFLELT NAVLWSLPLD IAGKYAGTAG
     GMMNTGFGVA GMVSPVVFGY LIERTGSYDL PFMISGALLG VGALASLFIN PLLTVDSPDE
     KAGEVRHALP