ID   SAUV_PHYSA              Reviewed;          40 AA.
AC   P01144;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Sauvagin;
DE   AltName: Full=Sauvagine;
DE            Short=SVG;
OS   Phyllomedusa sauvagei (Sauvage's leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8395;
RN   [1]
RP   PRELIMINARY PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RA   Montecucchi P.C., Henschen A., Erspamer V.;
RT   "Structure of sauvagine, a vasoactive peptide from the skin of a frog.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 360:1178-1178(1979).
RN   [2]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   ILE-40.
RC   TISSUE=Skin secretion;
RX   PubMed=7309372; DOI=10.1111/j.1399-3011.1981.tb02047.x;
RA   Montecucchi P.C., Anastasi A., de Castiglione R., Erspamer V.;
RT   "Amino acid composition and sequence analysis of sauvagine, a new active
RT   peptide from the skin of Phyllomedusa sauvagei.";
RL   Int. J. Pept. Protein Res. 18:113-120(1981).
RN   [3]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=7118402;
RA   Montecucchi P.C., Henschen A.;
RT   "Primary structure of sauvagine.";
RL   Int. J. Pept. Protein Res. 19:325-325(1982).
RN   [4]
RP   SYNTHESIS.
RX   PubMed=3378281; DOI=10.1248/cpb.36.122;
RA   Nomizu M., Akaji K., Fukata J., Imura H., Inoue A., Nakata Y., Segawa T.,
RA   Fujii N., Yajima H.;
RT   "Studies on peptides. CLVII. Synthesis of frog-skin peptide, sauvagine.";
RL   Chem. Pharm. Bull. 36:122-133(1988).
RN   [5]
RP   SECONDARY STRUCTURE PREDICTION.
RX   PubMed=6981615; DOI=10.1111/j.1399-3011.1982.tb02666.x;
RA   Montecucchi P.C., Gozzini L.;
RT   "Secondary structure prediction of sauvagine, a novel biologically active
RT   polypeptide from a frog.";
RL   Int. J. Pept. Protein Res. 20:139-143(1982).
CC   -!- FUNCTION: Hypotensive and diuretic peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; A01406; SWFGS.
DR   AlphaFoldDB; P01144; -.
DR   SMR; P01144; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..40
FT                   /note="Sauvagin"
FT                   /id="PRO_0000044693"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:7309372"
FT   MOD_RES         40
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:7309372"
SQ   SEQUENCE   40 AA;  4617 MW;  1E3CD73D61128C4F CRC64;
     QGPPISIDLS LELLRKMIEI EKQEKEKQQA ANNRLLLDTI