SAV1_STRVL
ID SAV1_STRVL Reviewed; 183 AA.
AC Q53532;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Streptavidin-V1;
DE Short=SA V1;
DE Flags: Precursor;
OS Streptomyces violaceus (Streptomyces venezuelae).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=1936;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7632734; DOI=10.1016/0167-4781(95)00077-t;
RA Bayer E.A., Kulik T., Adar R., Wilchek M.;
RT "Close similarity among streptavidin-like, biotin-binding proteins from
RT Streptomyces.";
RL Biochim. Biophys. Acta 1263:60-66(1995).
CC -!- FUNCTION: The biological function of streptavidin is not known. Forms a
CC strong non-covalent specific complex with biotin (one molecule of
CC biotin per subunit of streptavidin).
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|PROSITE-ProRule:PRU00656}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the avidin/streptavidin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; S78777; AAB35015.1; -; Genomic_DNA.
DR AlphaFoldDB; Q53532; -.
DR SMR; Q53532; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009374; F:biotin binding; IEA:InterPro.
DR Gene3D; 2.40.128.30; -; 1.
DR InterPro; IPR005469; Avidin.
DR InterPro; IPR017889; Avidin-like_CS.
DR InterPro; IPR036896; Avidin-like_sf.
DR InterPro; IPR005468; Avidin/str.
DR Pfam; PF01382; Avidin; 1.
DR PRINTS; PR00709; AVIDIN.
DR SUPFAM; SSF50876; SSF50876; 1.
DR PROSITE; PS00577; AVIDIN_1; 1.
DR PROSITE; PS51326; AVIDIN_2; 1.
PE 3: Inferred from homology;
KW Biotin; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..183
FT /note="Streptavidin-V1"
FT /id="PRO_0000002730"
FT DOMAIN 37..159
FT /note="Avidin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00656"
FT MOTIF 83..85
FT /note="Cell attachment site; atypical"
FT BINDING 67
FT /ligand="biotin"
FT /ligand_id="ChEBI:CHEBI:57586"
FT /evidence="ECO:0000250"
FT BINDING 78
FT /ligand="biotin"
FT /ligand_id="ChEBI:CHEBI:57586"
FT /evidence="ECO:0000250"
FT BINDING 116
FT /ligand="biotin"
FT /ligand_id="ChEBI:CHEBI:57586"
FT /evidence="ECO:0000250"
FT BINDING 132
FT /ligand="biotin"
FT /ligand_id="ChEBI:CHEBI:57586"
FT /evidence="ECO:0000250"
FT BINDING 144
FT /ligand="biotin"
FT /ligand_id="ChEBI:CHEBI:57586"
FT /evidence="ECO:0000250"
SQ SEQUENCE 183 AA; 18864 MW; 4652D8BB14847DE0 CRC64;
MRKIVVAAIA VSLTTVSITA SASADPSKDS KAQVSAAEAG ITGTWYNQLG STFIVTAGAD
GALTGTYESA VGNAESRYVL TGRYDSAPAT DGSGTALGWT VAWKNNYRNA HSATTWSGQY
VGGTEARINT QWLLTSGTTE ANAWKSTLVG HDTFTKVKPS AASIDAAKKA GVNNGNPLDA
VQQ