ID   SAX1_CHICK              Reviewed;         232 AA.
AC   P19601;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Homeobox protein SAX-1;
DE   AltName: Full=CHOX-3;
DE   Flags: Fragment;
GN   Name=SAX1; Synonyms=CHOX-3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2568317; DOI=10.1016/0378-1119(89)90008-5;
RA   Rangini Z., Frumkin A., Shani G., Guttmann M., Eyal-Giladi H.,
RA   Gruenbaum Y., Fainsod A.;
RT   "The chicken homeo box genes CHox1 and CHox3: cloning, sequencing and
RT   expression during embryogenesis.";
RL   Gene 76:61-74(1989).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Transiently expressed in the birth zone of the
CC       whole spinal cord regardless of the axial level.
CC   -!- SIMILARITY: Belongs to the NK-1 homeobox family. {ECO:0000305}.
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DR   EMBL; M23065; AAA48821.1; -; Genomic_DNA.
DR   PIR; JU0069; JU0069.
DR   AlphaFoldDB; P19601; -.
DR   SMR; P19601; -.
DR   VEuPathDB; HostDB:geneid_100857765; -.
DR   InParanoid; P19601; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..232
FT                   /note="Homeobox protein SAX-1"
FT                   /id="PRO_0000049289"
FT   DNA_BIND        65..124
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   232 AA;  25223 MW;  7326B84E381555C1 CRC64;
     CLPDPAALSR RCTHPGGERR GGSGRGGAAS GRRRVRFVSA VPGPEEPGSP RGGRRRRAEA
     SCAKPRRART AFTYEQLVAL ENKFRATRYL SVCERLNLAL SLSLTETQVK IWFQNRRTKW
     KKQHPGADGA AAPAPPAAAR CSPSPPRPAA LPGQTFPSYA ATSALFPAAS PFPPGRPRRR
     TLRSLLGARV PRASTPRTSE NPPRLCPSAP GVRNRVFLLR LASTKRKNTY ML