SAXO1_HUMAN
ID SAXO1_HUMAN Reviewed; 474 AA.
AC Q8IYX7; A8K880; Q5VY58;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Stabilizer of axonemal microtubules 1 {ECO:0000303|PubMed:25673876};
GN Name=SAXO1; Synonyms=C9orf138, FAM154A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-27 AND SER-63.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS GLU-27 AND
RP SER-63.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-27 AND SER-63.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, ASSOCIATION WITH MICROTUBULES, SUBUNIT, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP 116-ARG--PRO-119.
RX PubMed=25673876; DOI=10.1242/jcs.155143;
RA Dacheux D., Roger B., Bosc C., Landrein N., Roche E., Chansel L., Trian T.,
RA Andrieux A., Papaxanthos-Roche A., Marthan R., Robinson D.R., Bonhivers M.;
RT "Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to
RT cilia and related structures.";
RL J. Cell Sci. 128:1294-1307(2015).
CC -!- FUNCTION: May play a role in the regulation of cilium length.
CC Stabilizes microtubules at low temperature.
CC {ECO:0000269|PubMed:25673876}.
CC -!- SUBUNIT: Associates with microtubules via the Mn regions.
CC {ECO:0000269|PubMed:25673876}.
CC -!- INTERACTION:
CC Q8IYX7; P35609: ACTN2; NbExp=7; IntAct=EBI-3957636, EBI-77797;
CC Q8IYX7; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-3957636, EBI-357530;
CC Q8IYX7; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-3957636, EBI-742909;
CC Q8IYX7; O95429: BAG4; NbExp=3; IntAct=EBI-3957636, EBI-2949658;
CC Q8IYX7; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-3957636, EBI-742722;
CC Q8IYX7; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-3957636, EBI-11976299;
CC Q8IYX7; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-3957636, EBI-11530605;
CC Q8IYX7; P55273: CDKN2D; NbExp=3; IntAct=EBI-3957636, EBI-745859;
CC Q8IYX7; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-3957636, EBI-749051;
CC Q8IYX7; Q8IWX8: CHERP; NbExp=3; IntAct=EBI-3957636, EBI-2555370;
CC Q8IYX7; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-3957636, EBI-12012272;
CC Q8IYX7; P46108: CRK; NbExp=3; IntAct=EBI-3957636, EBI-886;
CC Q8IYX7; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3957636, EBI-3867333;
CC Q8IYX7; Q86V42: FAM124A; NbExp=3; IntAct=EBI-3957636, EBI-744506;
CC Q8IYX7; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-3957636, EBI-2510157;
CC Q8IYX7; Q14192: FHL2; NbExp=4; IntAct=EBI-3957636, EBI-701903;
CC Q8IYX7; Q13643: FHL3; NbExp=9; IntAct=EBI-3957636, EBI-741101;
CC Q8IYX7; Q5TD97: FHL5; NbExp=3; IntAct=EBI-3957636, EBI-750641;
CC Q8IYX7; P14136: GFAP; NbExp=3; IntAct=EBI-3957636, EBI-744302;
CC Q8IYX7; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-3957636, EBI-748515;
CC Q8IYX7; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-3957636, EBI-5460660;
CC Q8IYX7; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-3957636, EBI-748420;
CC Q8IYX7; O75031: HSF2BP; NbExp=3; IntAct=EBI-3957636, EBI-7116203;
CC Q8IYX7; Q8NA54: IQUB; NbExp=3; IntAct=EBI-3957636, EBI-10220600;
CC Q8IYX7; Q2TBA0: KLHL40; NbExp=3; IntAct=EBI-3957636, EBI-7851314;
CC Q8IYX7; P25800: LMO1; NbExp=3; IntAct=EBI-3957636, EBI-8639312;
CC Q8IYX7; P25791: LMO2; NbExp=4; IntAct=EBI-3957636, EBI-739696;
CC Q8IYX7; P25791-3: LMO2; NbExp=3; IntAct=EBI-3957636, EBI-11959475;
CC Q8IYX7; P45984: MAPK9; NbExp=3; IntAct=EBI-3957636, EBI-713568;
CC Q8IYX7; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-3957636, EBI-11750983;
CC Q8IYX7; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-3957636, EBI-10297093;
CC Q8IYX7; O43482: OIP5; NbExp=3; IntAct=EBI-3957636, EBI-536879;
CC Q8IYX7; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-3957636, EBI-9057006;
CC Q8IYX7; Q99471: PFDN5; NbExp=3; IntAct=EBI-3957636, EBI-357275;
CC Q8IYX7; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-3957636, EBI-949255;
CC Q8IYX7; Q8IYS1: PM20D2; NbExp=3; IntAct=EBI-3957636, EBI-11339910;
CC Q8IYX7; O15160: POLR1C; NbExp=3; IntAct=EBI-3957636, EBI-1055079;
CC Q8IYX7; O60504: SORBS3; NbExp=3; IntAct=EBI-3957636, EBI-741237;
CC Q8IYX7; O75716: STK16; NbExp=6; IntAct=EBI-3957636, EBI-749295;
CC Q8IYX7; Q13470-2: TNK1; NbExp=3; IntAct=EBI-3957636, EBI-11018037;
CC Q8IYX7; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-3957636, EBI-492476;
CC Q8IYX7; Q15654: TRIP6; NbExp=3; IntAct=EBI-3957636, EBI-742327;
CC Q8IYX7; Q548N1: VPS28; NbExp=3; IntAct=EBI-3957636, EBI-10243107;
CC Q8IYX7; Q9UK41: VPS28; NbExp=3; IntAct=EBI-3957636, EBI-727424;
CC Q8IYX7; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-3957636, EBI-12040603;
CC Q8IYX7; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-3957636, EBI-12030590;
CC Q8IYX7; Q96E35: ZMYND19; NbExp=6; IntAct=EBI-3957636, EBI-746595;
CC Q8IYX7; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-3957636, EBI-3957603;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000269|PubMed:25673876}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000269|PubMed:25673876}.
CC Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25673876}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000269|PubMed:25673876}. Note=In multi-ciliated cells,
CC localizes to the basal bodies and in non-ciliated cells, to the
CC centrosome. In spermatozoa, colocalizes with microtubules along the
CC length of the axoneme from its proximal end to its distal tip and with
CC tubulin at the distal end of the flagellum and at the proximal
CC centriole. {ECO:0000269|PubMed:25673876}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in testis.
CC Expressed in mature spermatozoa (at protein level).
CC {ECO:0000269|PubMed:25673876}.
CC -!- DEVELOPMENTAL STAGE: In retinal pigment epithelium (RPE1) cell line,
CC after 24 hours of serum starvation to stimulate primary cilium
CC production, present at the mother and daughter basal bodies. At early
CC time points of ciliogenesis, not detected in the axoneme. At later time
CC points, expressed along the axoneme, with increasing levels as
CC maturation of the cilium proceeds. {ECO:0000269|PubMed:25673876}.
CC -!- DOMAIN: The Mn regions are involved in microtubule-binding and
CC stabilization at low temperature. They are required and sufficient for
CC cilium targeting. {ECO:0000269|PubMed:25673876}.
CC -!- DOMAIN: The N-terminal region (residues 1-29) might play a role in
CC centriole retention. {ECO:0000269|PubMed:25673876}.
CC -!- SIMILARITY: Belongs to the FAM154 family. {ECO:0000305}.
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DR EMBL; AK292245; BAF84934.1; -; mRNA.
DR EMBL; AL158150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471071; EAW58654.1; -; Genomic_DNA.
DR EMBL; BC033489; AAH33489.1; -; mRNA.
DR CCDS; CCDS6487.1; -.
DR RefSeq; NP_001273978.1; NM_001287049.1.
DR RefSeq; NP_001273979.1; NM_001287050.1.
DR RefSeq; NP_714918.2; NM_153707.3.
DR AlphaFoldDB; Q8IYX7; -.
DR BioGRID; 127666; 53.
DR IntAct; Q8IYX7; 49.
DR STRING; 9606.ENSP00000369907; -.
DR iPTMnet; Q8IYX7; -.
DR PhosphoSitePlus; Q8IYX7; -.
DR BioMuta; SAXO1; -.
DR DMDM; 73620045; -.
DR MassIVE; Q8IYX7; -.
DR PaxDb; Q8IYX7; -.
DR PeptideAtlas; Q8IYX7; -.
DR PRIDE; Q8IYX7; -.
DR ProteomicsDB; 71259; -.
DR Antibodypedia; 10233; 45 antibodies from 15 providers.
DR DNASU; 158297; -.
DR Ensembl; ENST00000380534.9; ENSP00000369907.4; ENSG00000155875.15.
DR GeneID; 158297; -.
DR KEGG; hsa:158297; -.
DR MANE-Select; ENST00000380534.9; ENSP00000369907.4; NM_153707.4; NP_714918.2.
DR UCSC; uc003zni.4; human.
DR CTD; 158297; -.
DR DisGeNET; 158297; -.
DR GeneCards; SAXO1; -.
DR HGNC; HGNC:28566; SAXO1.
DR HPA; ENSG00000155875; Tissue enriched (testis).
DR MIM; 616292; gene.
DR neXtProt; NX_Q8IYX7; -.
DR OpenTargets; ENSG00000155875; -.
DR PharmGKB; PA162386652; -.
DR VEuPathDB; HostDB:ENSG00000155875; -.
DR eggNOG; ENOG502QWHB; Eukaryota.
DR GeneTree; ENSGT00390000007252; -.
DR HOGENOM; CLU_047658_0_0_1; -.
DR InParanoid; Q8IYX7; -.
DR OMA; TTAQAHY; -.
DR OrthoDB; 732196at2759; -.
DR PhylomeDB; Q8IYX7; -.
DR TreeFam; TF319394; -.
DR PathwayCommons; Q8IYX7; -.
DR SignaLink; Q8IYX7; -.
DR BioGRID-ORCS; 158297; 12 hits in 1070 CRISPR screens.
DR ChiTaRS; SAXO1; human.
DR GenomeRNAi; 158297; -.
DR Pharos; Q8IYX7; Tbio.
DR PRO; PR:Q8IYX7; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8IYX7; protein.
DR Bgee; ENSG00000155875; Expressed in secondary oocyte and 39 other tissues.
DR ExpressionAtlas; Q8IYX7; baseline and differential.
DR Genevisible; Q8IYX7; HS.
DR GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0070417; P:cellular response to cold; IDA:UniProtKB.
DR GO; GO:0009631; P:cold acclimation; IDA:UniProtKB.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IMP:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; IDA:UniProtKB.
DR InterPro; IPR033336; SAXO1/2.
DR PANTHER; PTHR31516; PTHR31516; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Flagellum; Reference proteome; Repeat.
FT CHAIN 1..474
FT /note="Stabilizer of axonemal microtubules 1"
FT /id="PRO_0000089737"
FT REGION 30..64
FT /note="Mn 1"
FT REGION 65..97
FT /note="Mn 2"
FT REGION 98..131
FT /note="Mn 3"
FT REGION 132..165
FT /note="Mn 4"
FT REGION 166..199
FT /note="Mn 5"
FT REGION 200..232
FT /note="Mn 6"
FT REGION 233..266
FT /note="Mn 7"
FT REGION 267..299
FT /note="Mn 8"
FT REGION 300..332
FT /note="Mn 9"
FT REGION 333..366
FT /note="Mn 10"
FT REGION 367..400
FT /note="Mn 12"
FT REGION 401..434
FT /note="Mn 12"
FT REGION 446..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 27
FT /note="K -> E (in dbSNP:rs7021572)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023229"
FT VARIANT 63
FT /note="P -> S (in dbSNP:rs6475273)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023230"
FT VARIANT 385
FT /note="N -> S (in dbSNP:rs34119945)"
FT /id="VAR_057807"
FT MUTAGEN 116..119
FT /note="RVDP->AADA: No effect on subcellular location."
FT /evidence="ECO:0000269|PubMed:25673876"
SQ SEQUENCE 474 AA; 54621 MW; 8D4525BEDE11F5D8 CRC64;
MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR ESFKPRREYQ
KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD LLTTYKKDYN PYPVCRVDPI
KPRDSKYPCS DKMECLPTYK ADYLPWNQPR REPLRLEHKY QPASVRFDNR TTHQDDYPIK
GLVKTISCKP LAMPKLCNIP LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ
KQSYRGLMGE PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR
MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM RTEPVKPVPQ
LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV PVESQTTYTI SFTPKEMGRC
LASYPEPPGY TFEEVDALGH RIYKPVSQAG SQQSSHLSVD DSENPNQREL EVLA
