ID   SAXO2_MOUSE             Reviewed;         394 AA.
AC   Q8BQB6; G3X9C9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Stabilizer of axonemal microtubules 2;
GN   Name=Saxo2; Synonyms=Fam154b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the FAM154 family. {ECO:0000305}.
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DR   EMBL; AK051095; BAC34522.1; -; mRNA.
DR   EMBL; AC138270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466543; EDL06900.1; -; Genomic_DNA.
DR   CCDS; CCDS21409.1; -.
DR   RefSeq; NP_808562.3; NM_177894.4.
DR   AlphaFoldDB; Q8BQB6; -.
DR   STRING; 10090.ENSMUSP00000057993; -.
DR   iPTMnet; Q8BQB6; -.
DR   PhosphoSitePlus; Q8BQB6; -.
DR   MaxQB; Q8BQB6; -.
DR   PaxDb; Q8BQB6; -.
DR   PRIDE; Q8BQB6; -.
DR   ProteomicsDB; 256708; -.
DR   Antibodypedia; 52475; 31 antibodies from 12 providers.
DR   DNASU; 330577; -.
DR   Ensembl; ENSMUST00000056728; ENSMUSP00000057993; ENSMUSG00000038570.
DR   GeneID; 330577; -.
DR   KEGG; mmu:330577; -.
DR   UCSC; uc009idb.1; mouse.
DR   CTD; 283726; -.
DR   MGI; MGI:1914618; Saxo2.
DR   VEuPathDB; HostDB:ENSMUSG00000038570; -.
DR   eggNOG; ENOG502QWHB; Eukaryota.
DR   GeneTree; ENSGT00390000007252; -.
DR   HOGENOM; CLU_047658_0_0_1; -.
DR   InParanoid; Q8BQB6; -.
DR   OMA; ERCTVQK; -.
DR   OrthoDB; 732196at2759; -.
DR   PhylomeDB; Q8BQB6; -.
DR   TreeFam; TF319394; -.
DR   BioGRID-ORCS; 330577; 1 hit in 73 CRISPR screens.
DR   PRO; PR:Q8BQB6; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8BQB6; protein.
DR   Bgee; ENSMUSG00000038570; Expressed in spermatid and 102 other tissues.
DR   ExpressionAtlas; Q8BQB6; baseline and differential.
DR   Genevisible; Q8BQB6; MM.
DR   GO; GO:0005879; C:axonemal microtubule; IBA:GO_Central.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   InterPro; IPR033336; SAXO1/2.
DR   PANTHER; PTHR31516; PTHR31516; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..394
FT                   /note="Stabilizer of axonemal microtubules 2"
FT                   /id="PRO_0000321840"
FT   CONFLICT        49
FT                   /note="F -> L (in Ref. 1; BAC34522)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   394 AA;  45533 MW;  57C248E401816259 CRC64;
     MRNWCLCQIC TCGSDYRPYE IVKQPRHIPE EYKPKQGKID LGTTYKRDFN PYKVQPLIKV
     RPVERQQVKK GKLDTVPTYK DDYRSWDIQK CELCKPEQAY HPPDVKFGNS TTFQDDYVPQ
     EIKPRQSFKP CSVVKCSVGP FNGDTSHRRD YVPHQLEVKF ARPKEIYKPT DQPFEDLTTH
     RNDFQGLAGE TAKICRPAYT RVTQNIQFKG STEFRDSFQP WEIPPPKVKK VAEYVPPSGS
     MQLNSTSHLD YVPYQASRVV AIRPVSHRRQ SNFPFQGKST TKEDFPAWEI CRQGLIKQQQ
     QIPNPSGKFE GLSTFRSHFV PHELIPTESC KPLNEALKSS VPLDDVTMYS IQFTPKKQEI
     CPASYPSPPG YIFENTNSQG HKFFRKIIPA VKAF