ID   SBCC_LACLA              Reviewed;        1046 AA.
AC   Q9CFZ0;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Nuclease SbcCD subunit C;
GN   Name=sbcC; OrderedLocusNames=LL1321; ORFNames=L152588;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily. {ECO:0000305}.
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DR   EMBL; AE005176; AAK05419.1; -; Genomic_DNA.
DR   PIR; A86790; A86790.
DR   RefSeq; NP_267477.1; NC_002662.1.
DR   RefSeq; WP_010905885.1; NC_002662.1.
DR   AlphaFoldDB; Q9CFZ0; -.
DR   STRING; 272623.L152588; -.
DR   PaxDb; Q9CFZ0; -.
DR   PRIDE; Q9CFZ0; -.
DR   EnsemblBacteria; AAK05419; AAK05419; L152588.
DR   KEGG; lla:L152588; -.
DR   PATRIC; fig|272623.7.peg.1425; -.
DR   eggNOG; COG0419; Bacteria.
DR   HOGENOM; CLU_004785_2_0_9; -.
DR   OMA; ISHVQEM; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; DNA recombination; DNA replication; Endonuclease;
KW   Exonuclease; Hydrolase; Nuclease; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1046
FT                   /note="Nuclease SbcCD subunit C"
FT                   /id="PRO_0000105865"
FT   COILED          223..239
FT                   /evidence="ECO:0000255"
FT   COILED          268..432
FT                   /evidence="ECO:0000255"
FT   COILED          468..505
FT                   /evidence="ECO:0000255"
FT   COILED          543..867
FT                   /evidence="ECO:0000255"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1046 AA;  120200 MW;  8F70D00AC28F8691 CRC64;
     MKPIYLEMNY FGPHENSVVD FRLLDESPIF LISGDTGAGK STIFDAMTYA LFGTTTGDRD
     AKEMRSQFAT ADDRTSVTFY FKQGNLLYRI ERSPEQKLSK KRGSGSTLQK STAKLAIVDR
     VKGIEKNNIA INPKNVGEEI TRLLHLNAEQ FKKIILLPQN DFSRFLKSST PDKEAILKRI
     FGTYIFTSFS NEIKAKNSEM NAVYLEYDRK QQNLYESSIW NPIELKELED AAEQEKLDLV
     TSLWKDRVAR KNEIEGQTFE QEEKVISIEI AYKSALELEN QFKNLNNLEN DYQQNIIEKS
     AIFEENSEYL KKLKWAFPLK ESIHELEQDI KQSKSVKNNI AGIISEKAKD EILLKKLTNE
     KEDLNKQQEN INENKKVAEK IFIQIQLSLQ VEKKQSKVEE LKLEQADNLT LLESFKANLG
     QAAENISTLQ DDVISDDYFI NKREERNQLE LTFRGKLIPT FQKVKHSKDD IVGLELKLKE
     NTIALSENKD NLEKAKFAYN EKLKGRRRLM IAQLQSELQE GEACPVCGAL EHPFTETIEE
     SSYKELGNLL KEIDESQKKQ TVLLEKNKQL QQLKTELKTS LDLKKIEADE FEKELSILYS
     EFIADYSQIF PDSFDEVSID ESLLNLTKSL ELEEVKNDET KVKLADLESK KLELQEKVKD
     FEYSNQEFNR QIENLNAEIT EIGITETSYN LIRKRNRLME KADLFEKHLS ELMAQLSDIK
     IKISSQTASL NSFESQEATL LERISANKEK IKEKFSEQEA FTTEFQILKE WAYDDDLIQI
     SQKVEQYKAD KARLKVEIKN IQQLIQNKKR PNLALIEEEK KQTNENYVFL QKKLVSAENE
     VEQAKSILSE LKKVIKQQDK DASKKSAITK LYNAISGRAS EDKLRLETYV VQNYLEKILD
     YANLHFINQL SNNRYRFELA GEGNNRRMDH GLDINIYDNE TGAARSADTL SGGETFIAAL
     SIALALSEVV QNTANGVQIE ALFIDEGFGS LDQETLQKAM QALEQIGENR LVGVISHVEE
     MKATIGQRII INKMGDGRSN IKSVIK