ID   SBCC_PSEAE              Reviewed;        1211 AA.
AC   Q9HWB8;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Nuclease SbcCD subunit C;
GN   Name=sbcC; OrderedLocusNames=PA4282;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily. {ECO:0000305}.
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DR   EMBL; AE004091; AAG07670.1; -; Genomic_DNA.
DR   PIR; C83110; C83110.
DR   RefSeq; NP_252972.1; NC_002516.2.
DR   RefSeq; WP_003114994.1; NZ_QZGE01000034.1.
DR   AlphaFoldDB; Q9HWB8; -.
DR   SMR; Q9HWB8; -.
DR   STRING; 287.DR97_1457; -.
DR   PaxDb; Q9HWB8; -.
DR   PRIDE; Q9HWB8; -.
DR   EnsemblBacteria; AAG07670; AAG07670; PA4282.
DR   GeneID; 881690; -.
DR   KEGG; pae:PA4282; -.
DR   PATRIC; fig|208964.12.peg.4484; -.
DR   PseudoCAP; PA4282; -.
DR   HOGENOM; CLU_004785_1_1_6; -.
DR   InParanoid; Q9HWB8; -.
DR   OMA; ISHVQEM; -.
DR   PhylomeDB; Q9HWB8; -.
DR   BioCyc; PAER208964:G1FZ6-4366-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; DNA recombination; DNA replication; Endonuclease;
KW   Exonuclease; Hydrolase; Nuclease; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1211
FT                   /note="Nuclease SbcCD subunit C"
FT                   /id="PRO_0000105866"
FT   REGION          62..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          115..156
FT                   /evidence="ECO:0000255"
FT   COILED          197..407
FT                   /evidence="ECO:0000255"
FT   COILED          497..584
FT                   /evidence="ECO:0000255"
FT   COILED          628..1048
FT                   /evidence="ECO:0000255"
FT   BINDING         37..44
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1211 AA;  138960 MW;  FC8DCA6656C08E42 CRC64;
     MKILAIRLKN LASLAGEQEI DFTREPLSSA GLFAITGPTG AGKSTVLDAL CLALFGSTPR
     LESTSASSKV PDGRNELSSN DERNLLRRGC ASGYAEVDFV GIDGHRYRAR WETRRSRDKA
     DGALQKSQQS LQDLETQQML AANKKSEFRE QLEQKLGLNF AQFTRAVLLA QSEFSAFLKA
     SDNDRGALLE KLTDTGLYSQ LSKAAYQRAS QADEQRKQLE QRLEGSLPLA EQARAGLEAA
     LESHAQARLQ EQQALQRLEG QQQWFTEEQR LLQSCEHAQG QLAEARQAWD ALATERETLQ
     WLERLAPVRG LIERLKQLEQ ELRHSEQQQR QRTEQQAAGT ERLQGLQARL QEARERQAQA
     DNHLRQAQAP LREAFQLESE ARRLERTLAE RQELHRQSNQ RHAQQSDAAR QLDMEQQRHV
     AEQAQLQAAL RDSQALAALG DAWVTHQGQL ATFVQRRQRA LESQAQLPEL EKSLAHAGEP
     LERLQAQWTA LHGSEPDDLA ARLVELRRQT DSLERQQALH KEWQQVLDQR AGLARRLGEL
     DQRMVEQEQA LLDLKRQGSQ CAEEVKAAEQ ALQVTRELLQ RQRLARSASV EQLRAGLVDG
     EACPVCGSQE HPYHHSEQLL AALGEHDDQE QVRAEQSLER LRQTLVGLRE GYSSQRERLN
     QSRQEQQELT GQLAALDRQL DQWTLPEELR LLQPSAQLEW LAQRLDDLAG QRQQCQRDFD
     RLIARQRQTQ QLQQELRAAE TILQQRQQAL TEQRQRYEHL QQQVEEDSQQ LRPLLSDEHW
     QRWQADPLRT FQALGESIEQ RRQQQARLQQ IEQRLQELKQ RCDESSWQLK QSDEQRNEAR
     QAEERAQAEL AELNGRLGAH LGQHACAQDW QLSLEHAAQA AQSAVETLQA PLDSLREEQL
     RLAEALEHLQ QQRQRQQDEF QRLQADWQAW RERQDNLDDS RLDALLGLSE EQATQWREQL
     QRLQEEITRQ QTLEAERQAQ LLQHRRQRPE TDREALEDNL RQQRERLAAS EQAYLETYSQ
     LQADNQRREQ SQALLAELER ARAEFRRWGR LNELIGSSSG DKFRRIAQGY NLDLLVQHSN
     VQLRQLARRY RLQRGGSELG LLVVDTEMGD ELRSVYSLSG GETFLISLAL ALGLASMASS
     KLRIESLFID EGFGSLDPES LQLAMDALDN LQAQGRKVAV ISHVQEMHER IPVQVRVQRE
     GNGMSSLKVV G