ID   SBCC_STAAB              Reviewed;        1009 AA.
AC   Q2YXX0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Nuclease SbcCD subunit C;
GN   Name=sbcC; OrderedLocusNames=SAB1204;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI80893.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ938182; CAI80893.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; Q2YXX0; -.
DR   KEGG; sab:SAB1204; -.
DR   HOGENOM; CLU_004785_2_1_9; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; DNA recombination; DNA replication; Endonuclease;
KW   Exonuclease; Hydrolase; Nuclease; Nucleotide-binding.
FT   CHAIN           1..1009
FT                   /note="Nuclease SbcCD subunit C"
FT                   /id="PRO_0000338460"
FT   COILED          176..208
FT                   /evidence="ECO:0000255"
FT   COILED          264..364
FT                   /evidence="ECO:0000255"
FT   COILED          392..501
FT                   /evidence="ECO:0000255"
FT   COILED          535..776
FT                   /evidence="ECO:0000255"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1009 AA;  117613 MW;  C18A8803F74B0F8F CRC64;
     MKPLHLKLNN FGPFLKEEID FSKIDNNELF LISGKTGSGK TMIFDAMTYA LFGKASTEQR
     EENDLRSHFA DGKQPMSVTF EFQLNHRIYK VHRQGPYIKE GNTTKTNAKF DVFEMVDGKY
     EIRESKVISG TQFIIELLGV NADQFRQLFI LPQGEFKRFL ISNSREKQGI LRTLFDSEKF
     EAIREILKEE VKKEKAQIEN RYQQIDLLWQ EIESFDDDKI KGLLEVATQQ IDKVIENIPL
     LQVRSKEILA FVNESKETAI KEYEIIEKKT LENNILKDNI NQLNKNKIDF VQLKEQQPEI
     EEIEAKLKLL QDITNLLNYI ENREKIETKI ANCKKDISKT NNKILNLECD KRTIDKEKKM
     LEENGDLIES KISFIDKTRV LFNDINKYQQ SYLNIERLRT EGEQLGDELN NLIKGLEKVE
     DSIGNNESDY EKIIELNNAI TNINNEINVI KENEKAKAEL DKLLGSKQEL ENQINEEKTI
     LKNLEIKLDR YDKSKLDLND KESFISEIKS AVKIGDQCPI CGNEIQDLGH HIDFDSIAKR
     QNEIKEIEAN IHTMKSNIAV HNFEIKFVNE KISNINIKTQ SDLSLEVLNK RLLENENALN
     NQRDLNKFIE QMKEEKDNLT LQIHNKQLRL NKNESELKIC RDLITEFETL SKYNNITNFE
     VDYKKYVQDV NQHQEHSKEI EDKLIQLSQR KLIEQNNLNH YENQLETYNN DLELNEQSIE
     MEMSRLNLTD DNDINEIIAW RGEQEELEQK RDTYKKRYHE FEMEIARLES LTKDKELLDS
     DKLIDEYELK KGKMNTLIDE YSAVHYQCQN NIKKTQSIVS HINYLNQELK DQQEIFQLAE
     IVSGKNNKNL TLENFVLIYY LDQIIAQANL RLATMSDNRY QLIRREAVSH GLSGLEIDVF
     DLHSNKSRHI SSLSGGETFQ SSLALALGLS EIVQQQSGGI SLESIFIDEG FGTLDQETLE
     TALDTLLNLK STGRMVGIIS HVSELKNRIP LVLEVKSDQY QSSTRFKRN