ID   SBCD_BACSU              Reviewed;         391 AA.
AC   P23479; O06711; O31595;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 5.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Nuclease SbcCD subunit D;
GN   Name=sbcD; Synonyms=yixA; OrderedLocusNames=BSU10640;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9353931; DOI=10.1099/00221287-143-10-3305;
RA   Medina N., Vannier F., Roche B., Autret S., Levine A., Seror S.J.;
RT   "Sequencing of regions downstream of addA (98 degrees) and citG (289
RT   degrees) in Bacillus subtilis.";
RL   Microbiology 143:3305-3308(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=10568751; DOI=10.1101/gr.9.11.1116;
RA   Medigue C., Rose M., Viari A., Danchin A.;
RT   "Detecting and analyzing DNA sequencing errors: toward a higher quality of
RT   the Bacillus subtilis genome sequence.";
RL   Genome Res. 9:1116-1127(1999).
RN   [4]
RP   SEQUENCE REVISION TO 193-194 AND 376.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-325.
RX   PubMed=1646786; DOI=10.1128/jb.173.12.3644-3655.1991;
RA   Kooistra J., Venema G.;
RT   "Cloning, sequencing, and expression of Bacillus subtilis genes involved in
RT   ATP-dependent nuclease synthesis.";
RL   J. Bacteriol. 173:3644-3655(1991).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=8493111; DOI=10.1093/nar/21.8.2010;
RA   Sharples G.J., Lloyd R.G.;
RT   "Location of the Bacillus subtilis sbcD gene downstream of addAB, the
RT   analogues of E. coli recBC.";
RL   Nucleic Acids Res. 21:2010-2010(1993).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SbcD family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA22202.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAA70669.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; Y09476; CAA70669.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL009126; CAB12904.3; -; Genomic_DNA.
DR   EMBL; M63489; AAA22202.1; ALT_FRAME; Genomic_DNA.
DR   PIR; C39432; C39432.
DR   RefSeq; NP_388945.3; NC_000964.3.
DR   RefSeq; WP_003233099.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; P23479; -.
DR   SMR; P23479; -.
DR   STRING; 224308.BSU10640; -.
DR   PaxDb; P23479; -.
DR   PRIDE; P23479; -.
DR   EnsemblBacteria; CAB12904; CAB12904; BSU_10640.
DR   GeneID; 936351; -.
DR   KEGG; bsu:BSU10640; -.
DR   PATRIC; fig|224308.179.peg.1144; -.
DR   eggNOG; COG0420; Bacteria.
DR   InParanoid; P23479; -.
DR   OMA; GNHDQHS; -.
DR   PhylomeDB; P23479; -.
DR   BioCyc; BSUB:BSU10640-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0004529; F:exodeoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006274; P:DNA replication termination; IBA:GO_Central.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR004593; SbcD.
DR   InterPro; IPR026843; SbcD_C.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF12320; SbcD_C; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   TIGRFAMs; TIGR00619; sbcd; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA recombination; Exonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..391
FT                   /note="Nuclease SbcCD subunit D"
FT                   /id="PRO_0000182193"
FT   CONFLICT        193..194
FT                   /note="ER -> DG (in Ref. 5; AAA22202)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        376
FT                   /note="K -> R (in Ref. 1; CAA70669)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   391 AA;  43492 MW;  E3C007CFB67156D5 CRC64;
     MRILHTADWH LGKTLEGRSR LSEQADVLDE LNTIVKDEQI DAIVMAGDAF DTVNPPALAE
     QLFYESLSAL SDRGKRPIVV IAGNHDNPDR LSAASPLTHE NGIHLIGYPT TEPIHIEVPS
     AGELLAVGAL AYPSEARLNE VLSDTFDEKL LRDHYDVKIR QAFEHMTSRF RTDAVKIAAS
     HIYVAGGNQT DSERPIEVGG AYTVAAESLP ADAAYVALGH LHRPQTIKRA RTLARYSGSP
     LAYSFSEAGY AKSVTIVDAK PGEEATWQEV LLSSGKPLVK WKAANGLSEV YSWLDEGRDQ
     NAWIDLEIRV ADQLSLEEIH RLRKAHPGFI HIRPVFEEQN KDRERIEVKH VSIEDRFKKF
     YEKQTGGAVP DEEMVKLFLE LASGVEEEDA K