ID   SBCD_STAA8              Reviewed;         373 AA.
AC   Q2FYT4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Nuclease SbcCD subunit D;
GN   Name=sbcD; OrderedLocusNames=SAOUHSC_01341;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION IN SOS RESPONSE, AND INDUCTION BY CIPROFLOXACIN AND LEXA.
RX   PubMed=17085555; DOI=10.1128/jb.01464-06;
RA   Cirz R.T., Jones M.B., Gingles N.A., Minogue T.D., Jarrahi B.,
RA   Peterson S.N., Romesberg F.E.;
RT   "Complete and SOS-mediated response of Staphylococcus aureus to the
RT   antibiotic ciprofloxacin.";
RL   J. Bacteriol. 189:531-539(2007).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity (By similarity). Is probably part of the SOS
CC       regulon and involved in DNA recombination and repair. {ECO:0000250,
CC       ECO:0000269|PubMed:17085555}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000250}.
CC   -!- INDUCTION: Induced by ciprofloxacin and up-regulated by LexA.
CC       {ECO:0000269|PubMed:17085555}.
CC   -!- SIMILARITY: Belongs to the SbcD family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD30438.1; -; Genomic_DNA.
DR   RefSeq; WP_000691284.1; NZ_LS483365.1.
DR   RefSeq; YP_499870.1; NC_007795.1.
DR   AlphaFoldDB; Q2FYT4; -.
DR   SMR; Q2FYT4; -.
DR   STRING; 1280.SAXN108_1362; -.
DR   EnsemblBacteria; ABD30438; ABD30438; SAOUHSC_01341.
DR   GeneID; 3920205; -.
DR   KEGG; sao:SAOUHSC_01341; -.
DR   PATRIC; fig|93061.5.peg.1224; -.
DR   eggNOG; COG0420; Bacteria.
DR   HOGENOM; CLU_038045_0_1_9; -.
DR   OMA; TSGNHDS; -.
DR   PRO; PR:Q2FYT4; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004529; F:exodeoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006274; P:DNA replication termination; IBA:GO_Central.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR004593; SbcD.
DR   InterPro; IPR026843; SbcD_C.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF12320; SbcD_C; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   TIGRFAMs; TIGR00619; sbcd; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA recombination; DNA repair; DNA replication; Endonuclease;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome; SOS response.
FT   CHAIN           1..373
FT                   /note="Nuclease SbcCD subunit D"
FT                   /id="PRO_0000338488"
SQ   SEQUENCE   373 AA;  42936 MW;  2473F7EBD76CC5BE CRC64;
     MKIIHTADWH LGKILNGKQL LEDQAYILDM FVEKMKEEEP DIIVIAGDLY DTTYPSKDAI
     MLLEQAIGKL NLELRIPIII ISGNHDGKER LNYGASWFEH NQLFIRTDFT SINSPIEING
     VNFYTLPYAT VSEMKHYFED DTIETHQQGI TRCIETIAPE IDEDAVNILI SHLTVQGGKT
     SDSERPLTIG TVESVQKGVF DIFDYVMLGH LHHPFSIEDD KIKYSGSLLQ YSFSEAGQAK
     GYRRVTINDG IINDVFIPLK PLRQLEIISG EYNDVINEKV HVKNKDNYLH FKLKNMSHIT
     DPMMSLKQIY PNTLALTNET FNYNEENNAI EISEKDDMSI IEMFYKHITD KELSDIQSKK
     IKNILENELR KED