SBCD_STAAB
ID SBCD_STAAB Reviewed; 373 AA.
AC Q2YXX1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Nuclease SbcCD subunit D;
GN Name=sbcD; OrderedLocusNames=SAB1203;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC inhibit DNA replication and are intermediates in certain DNA
CC recombination reactions. The complex acts as a 3'->5' double strand
CC exonuclease that can open hairpins. It also has a 5' single-strand
CC endonuclease activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SbcD family. {ECO:0000305}.
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DR EMBL; AJ938182; CAI80892.1; -; Genomic_DNA.
DR RefSeq; WP_000691313.1; NC_007622.1.
DR AlphaFoldDB; Q2YXX1; -.
DR SMR; Q2YXX1; -.
DR KEGG; sab:SAB1203; -.
DR HOGENOM; CLU_038045_0_1_9; -.
DR OMA; TSGNHDS; -.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041796; Mre11_N.
DR InterPro; IPR004593; SbcD.
DR InterPro; IPR026843; SbcD_C.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF12320; SbcD_C; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
DR TIGRFAMs; TIGR00619; sbcd; 1.
PE 3: Inferred from homology;
KW DNA recombination; DNA replication; Endonuclease; Exonuclease; Hydrolase;
KW Nuclease.
FT CHAIN 1..373
FT /note="Nuclease SbcCD subunit D"
FT /id="PRO_0000338478"
SQ SEQUENCE 373 AA; 42915 MW; DD471D5023C06725 CRC64;
MKIIHTADWH LGKILNGKQL LEDQTYILDM FVEKMKEEEP DIIVIAGDLY DTTYPSKDAI
MLLEQAIGKL NLELRIPIIM ISGNHDGKER LNYGASWFEH NQLFIRTDFT SINSPIEING
VNFYTLPYAT VSEMKHYFED DTIETHQQGI TRCIETIAPA IDEVAVNILI SHLTVQGGKT
SDSERPLTIG TVESVQKGVF DIFDYVMLGH LHHPFSIEDD KIKYSGSLLQ YSFSEAGQAK
GYRRVTINDG IINDVFIPLK SLRQLEIISG EYNDVINEKV HVKNKDNYLH FKLKNMSHIT
DPMMSLKQIY PNTLALTNET FNYNEENNTI EISEKDDMSI IEMFYNHITD KKLSDIQSKK
IKNILENELR KED