ID   SBDS_BOVIN              Reviewed;         250 AA.
AC   Q3SWZ6;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Ribosome maturation protein SBDS;
DE   AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN   Name=SBDS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC       biogenesis. Together with EFL1, triggers the GTP-dependent release of
CC       EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating
CC       ribosomes for translation competence by allowing 80S ribosome assembly
CC       and facilitating EIF6 recycling to the nucleus, where it is required
CC       for 60S rRNA processing and nuclear export. Required for normal levels
CC       of protein synthesis. May play a role in cellular stress resistance.
CC       May play a role in cellular response to DNA damage. May play a role in
CC       cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. Interacts with
CC       NPM1, RPA1 and PRKDC. May interact with NIP7 (By similarity). Interacts
CC       with CLN3 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9Y3A5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC       cytoplasm, and at low levels in nucleus. Detected in the nucleolus
CC       during G1 and G2 phase of the cell cycle, and diffusely distributed in
CC       the nucleus during S phase. Detected at the mitotic spindle.
CC       Colocalizes with the microtubule organizing center during interphase
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR   EMBL; BC104585; AAI04586.1; -; mRNA.
DR   RefSeq; NP_001029611.1; NM_001034439.1.
DR   AlphaFoldDB; Q3SWZ6; -.
DR   BMRB; Q3SWZ6; -.
DR   SMR; Q3SWZ6; -.
DR   STRING; 9913.ENSBTAP00000005296; -.
DR   PaxDb; Q3SWZ6; -.
DR   PeptideAtlas; Q3SWZ6; -.
DR   PRIDE; Q3SWZ6; -.
DR   Ensembl; ENSBTAT00000005296; ENSBTAP00000005296; ENSBTAG00000004051.
DR   GeneID; 513237; -.
DR   KEGG; bta:513237; -.
DR   CTD; 51119; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004051; -.
DR   VGNC; VGNC:34304; SBDS.
DR   eggNOG; KOG2917; Eukaryota.
DR   GeneTree; ENSGT00390000008135; -.
DR   HOGENOM; CLU_043216_1_1_1; -.
DR   InParanoid; Q3SWZ6; -.
DR   OMA; AVNPQMD; -.
DR   OrthoDB; 1217666at2759; -.
DR   TreeFam; TF300881; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000004051; Expressed in subcutaneous adipose tissue and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0048539; P:bone marrow development; ISS:UniProtKB.
DR   GO; GO:0030282; P:bone mineralization; ISS:UniProtKB.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR   GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 1.10.10.900; -; 1.
DR   Gene3D; 3.30.1250.10; -; 1.
DR   InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR   InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR   InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR   InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR   InterPro; IPR002140; Sdo1/SBDS.
DR   InterPro; IPR039100; Sdo1/SBDS-like.
DR   InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR   PANTHER; PTHR10927; PTHR10927; 1.
DR   Pfam; PF01172; SBDS; 1.
DR   Pfam; PF09377; SBDS_C; 1.
DR   SUPFAM; SSF109728; SSF109728; 1.
DR   SUPFAM; SSF89895; SSF89895; 1.
DR   TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR   PROSITE; PS01267; UPF0023; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW   Reference proteome; Ribosome biogenesis.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3A5"
FT   CHAIN           2..250
FT                   /note="Ribosome maturation protein SBDS"
FT                   /id="PRO_0000245577"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3A5"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70122"
SQ   SEQUENCE   250 AA;  28718 MW;  5D8C1245327DAB02 CRC64;
     MSIFTPTNQI RLTNVAVVRM KRAGKRFEIA CYKNKVVGWR SGVEKDLDEV LQTHSVFVNV
     SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER HTQLEQMFRD IATIVADKCV
     NPETKRPYTV ILIERAMKDI HYSVKPNKST KQQALEVIKQ LKEKMKIERA HMRLRFILPV
     NEGKKLKEKL KPLIKVIESE DYGQQLEIVC LIDPGCFREV DELIKKETKG KGSLEVLSLK
     DVEEGDEKFE