ID   SBDS_CAEEL              Reviewed;         253 AA.
AC   Q23202;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Ribosome maturation protein SBDS;
DE   AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN   Name=sbds-1; ORFNames=W06E11.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC       biogenesis. Together with K10C3.5b/EFL1, triggers the GTP-dependent
CC       release of ribosome maturation factors from 60S pre-ribosomes in the
CC       cytoplasm, thereby activating ribosomes for translation competence by
CC       allowing 80S ribosome assembly. Required for normal levels of protein
CC       synthesis. May play a role in cellular stress resistance. May play a
CC       role in cellular response to DNA damage. May play a role in cell
CC       proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC       cytoplasm, and at low levels in nucleus and nucleolus. Detected at the
CC       mitotic spindle. Colocalizes with the microtubule organizing center
CC       during interphase (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR   EMBL; FO080477; CCD63990.1; -; Genomic_DNA.
DR   RefSeq; NP_497226.2; NM_064825.5.
DR   AlphaFoldDB; Q23202; -.
DR   SMR; Q23202; -.
DR   BioGRID; 40489; 1.
DR   STRING; 6239.W06E11.4; -.
DR   EPD; Q23202; -.
DR   PaxDb; Q23202; -.
DR   PeptideAtlas; Q23202; -.
DR   EnsemblMetazoa; W06E11.4.1; W06E11.4.1; WBGene00021063.
DR   GeneID; 175218; -.
DR   KEGG; cel:CELE_W06E11.4; -.
DR   UCSC; W06E11.4; c. elegans.
DR   CTD; 175218; -.
DR   WormBase; W06E11.4; CE30118; WBGene00021063; sbds-1.
DR   eggNOG; KOG2917; Eukaryota.
DR   GeneTree; ENSGT00390000008135; -.
DR   HOGENOM; CLU_043216_1_1_1; -.
DR   InParanoid; Q23202; -.
DR   OMA; AVNPQMD; -.
DR   OrthoDB; 1217666at2759; -.
DR   PhylomeDB; Q23202; -.
DR   PRO; PR:Q23202; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00021063; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   Gene3D; 1.10.10.900; -; 1.
DR   Gene3D; 3.30.1250.10; -; 1.
DR   InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR   InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR   InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR   InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR   InterPro; IPR002140; Sdo1/SBDS.
DR   InterPro; IPR039100; Sdo1/SBDS-like.
DR   InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR   PANTHER; PTHR10927; PTHR10927; 1.
DR   Pfam; PF01172; SBDS; 1.
DR   Pfam; PF09377; SBDS_C; 1.
DR   SUPFAM; SSF109728; SSF109728; 1.
DR   SUPFAM; SSF89895; SSF89895; 1.
DR   TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR   PROSITE; PS01267; UPF0023; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..253
FT                   /note="Ribosome maturation protein SBDS"
FT                   /id="PRO_0000123766"
SQ   SEQUENCE   253 AA;  28514 MW;  4C86D3CAFE5CB9FC CRC64;
     MSKNIKTPTN QKVLTNVAVV RMKKTGKRFE IACYKNKVVN WRNKSEKDID EVLQTHTVFS
     NVSKGQLSKK EELIAAFGIE DQLEICKIIL DKGDLQVSEK ERQAASDQSL KEVSQLIASM
     VVNPETKRPV PPSVIDKALQ EMHFSLKPNR SSKQQALDAI PKLRETLKIE RAKMKIRVAI
     PTKEAKSVHT KLKTLFSDVE VDDWQDGSLE MVGLIEPGSF RALDDLVRNE TKGHGRLEIL
     SLKDVVEGEL QIS