ID   SBDS_CHICK              Reviewed;         250 AA.
AC   Q5ZIY4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Ribosome maturation protein SBDS;
DE   AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN   Name=SBDS; ORFNames=RCJMB04_22m12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC       biogenesis. Together with EFL1, triggers the GTP-dependent release of
CC       EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating
CC       ribosomes for translation competence by allowing 80S ribosome assembly
CC       and facilitating EIF6 recycling to the nucleus, where it is required
CC       for 60S rRNA processing and nuclear export. Required for normal levels
CC       of protein synthesis. May play a role in cellular stress resistance.
CC       May play a role in cellular response to DNA damage. May play a role in
CC       cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC       cytoplasm, and at low levels in nucleus and nucleolus. Detected at the
CC       mitotic spindle. Colocalizes with the microtubule organizing center
CC       during interphase (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR   EMBL; AJ720650; CAG32309.1; -; mRNA.
DR   RefSeq; NP_001006211.1; NM_001006211.2.
DR   AlphaFoldDB; Q5ZIY4; -.
DR   SMR; Q5ZIY4; -.
DR   STRING; 9031.ENSGALP00000041256; -.
DR   PaxDb; Q5ZIY4; -.
DR   Ensembl; ENSGALT00000045256; ENSGALP00000041256; ENSGALG00000027989.
DR   GeneID; 417477; -.
DR   KEGG; gga:417477; -.
DR   CTD; 51119; -.
DR   VEuPathDB; HostDB:geneid_417477; -.
DR   eggNOG; KOG2917; Eukaryota.
DR   GeneTree; ENSGT00390000008135; -.
DR   HOGENOM; CLU_043216_1_1_1; -.
DR   InParanoid; Q5ZIY4; -.
DR   OMA; AVNPQMD; -.
DR   OrthoDB; 1217666at2759; -.
DR   PhylomeDB; Q5ZIY4; -.
DR   TreeFam; TF300881; -.
DR   PRO; PR:Q5ZIY4; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000027989; Expressed in muscle tissue and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
DR   Gene3D; 1.10.10.900; -; 1.
DR   Gene3D; 3.30.1250.10; -; 1.
DR   InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR   InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR   InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR   InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR   InterPro; IPR002140; Sdo1/SBDS.
DR   InterPro; IPR039100; Sdo1/SBDS-like.
DR   InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR   PANTHER; PTHR10927; PTHR10927; 1.
DR   Pfam; PF01172; SBDS; 1.
DR   Pfam; PF09377; SBDS_C; 1.
DR   SUPFAM; SSF109728; SSF109728; 1.
DR   SUPFAM; SSF89895; SSF89895; 1.
DR   TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR   PROSITE; PS01267; UPF0023; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..250
FT                   /note="Ribosome maturation protein SBDS"
FT                   /id="PRO_0000304734"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   250 AA;  28823 MW;  54B5337B998F2A2D CRC64;
     MSIFTPTNQI RLTNVAVVRA RRAGKRFEIA CYRNKVMGWR SGAEKDIDEV LQTHTVFVNV
     SKGQVAKKED LVRAFGTDDQ TEICKVILSK GELQVSDKER QTQLEQMFRD IATIVADKCV
     NPETKRPYTV ILIERAMKDI HYSVKPNKST KQQALEVIRQ LKETMQIERA HMRLRFILPV
     KEGKKLKEKL KPLIKVIENE DFHDQLEIVC LIDPGCFREI DELIRSETKG KGTLEVLSLK
     DVEEGDEKLE