ID   SBDS_DICDI              Reviewed;         274 AA.
AC   Q86KZ5; Q55A43;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Ribosome maturation protein SBDS;
GN   Name=sbds; ORFNames=DDB_G0272324;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16410554; DOI=10.1242/jcs.02753;
RA   Wessels D., Srikantha T., Yi S., Kuhl S., Aravind L., Soll D.R.;
RT   "The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein
RT   that localizes to the pseudopod of Dictyostelium amoebae during
RT   chemotaxis.";
RL   J. Cell Sci. 119:370-379(2006).
CC   -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC       biogenesis. Triggers the GTP-dependent release of ribosome maturation
CC       factors from 60S pre-ribosomes in the cytoplasm, thereby activating
CC       ribosomes for translation competence by allowing 80S ribosome assembly.
CC       Required for normal levels of protein synthesis. May play a role in
CC       cellular stress resistance. May play a role in cellular response to DNA
CC       damage. May play a role in cell proliferation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC       cytoplasm, and at low levels in nucleus and nucleolus. Detected at the
CC       mitotic spindle. Colocalizes with the microtubule organizing center
CC       during interphase (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71314.1; -; Genomic_DNA.
DR   RefSeq; XP_645141.1; XM_640049.1.
DR   AlphaFoldDB; Q86KZ5; -.
DR   SMR; Q86KZ5; -.
DR   STRING; 44689.DDB0233143; -.
DR   PaxDb; Q86KZ5; -.
DR   EnsemblProtists; EAL71314; EAL71314; DDB_G0272324.
DR   GeneID; 8618311; -.
DR   KEGG; ddi:DDB_G0272324; -.
DR   dictyBase; DDB_G0272324; sbds.
DR   eggNOG; KOG2917; Eukaryota.
DR   HOGENOM; CLU_043216_1_1_1; -.
DR   InParanoid; Q86KZ5; -.
DR   OMA; AVNPQMD; -.
DR   PhylomeDB; Q86KZ5; -.
DR   PRO; PR:Q86KZ5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031143; C:pseudopodium; IDA:dictyBase.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0042256; P:mature ribosome assembly; IMP:dictyBase.
DR   Gene3D; 1.10.10.900; -; 1.
DR   Gene3D; 3.30.1250.10; -; 1.
DR   InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR   InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR   InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR   InterPro; IPR002140; Sdo1/SBDS.
DR   InterPro; IPR039100; Sdo1/SBDS-like.
DR   InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR   PANTHER; PTHR10927; PTHR10927; 1.
DR   Pfam; PF01172; SBDS; 1.
DR   Pfam; PF09377; SBDS_C; 1.
DR   SUPFAM; SSF109728; SSF109728; 1.
DR   SUPFAM; SSF89895; SSF89895; 1.
DR   TIGRFAMs; TIGR00291; RNA_SBDS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..274
FT                   /note="Ribosome maturation protein SBDS"
FT                   /id="PRO_0000327822"
FT   REGION          249..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  30570 MW;  1EE8FB0C01B3F2A8 CRC64;
     MSIFTPVNNK TLTNIVVVRY KKGAAKFEIA CYPSKVQSYR SKIEKDLNEV IQIHRIFTNV
     SKGIIAKKDE LIKAFGTDNE QEIILLILEK GELQVSSKER DNQSEQTFKD IATIVAEKCV
     NTETQRPIPV SIIEKAMKDV HYSIHPTKSS KQQSLEVIKQ ISSVIPIQRA QMRLNITIPT
     KESKTLNRDK LMVLVSKIEE EDRDGGGLSI VCLVDPGSYR KIDELIKQET KGKGFIDIIN
     LAVAKEGETK INETGKSAPT STTTTTTTTT SSSK