ID   SBDS_PONAB              Reviewed;         250 AA.
AC   Q5RAZ2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Ribosome maturation protein SBDS;
DE   AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN   Name=SBDS;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC       biogenesis. Together with EFL1, triggers the GTP-dependent release of
CC       EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating
CC       ribosomes for translation competence by allowing 80S ribosome assembly
CC       and facilitating EIF6 recycling to the nucleus, where it is required
CC       for 60S rRNA processing and nuclear export. Required for normal levels
CC       of protein synthesis. May play a role in cellular stress resistance.
CC       May play a role in cellular response to DNA damage. May play a role in
CC       cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. Interacts with
CC       NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex
CC       consisting of the 60S ribosomal subunit, SBDS and EFL1. Interacts with
CC       CLN3 (By similarity). {ECO:0000250|UniProtKB:Q9Y3A5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC       cytoplasm, and at low levels in nucleus. Detected in the nucleolus
CC       during G1 and G2 phase of the cell cycle, and diffusely distributed in
CC       the nucleus during S phase. Detected at the mitotic spindle.
CC       Colocalizes with the microtubule organizing center during interphase
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR   EMBL; CR858869; CAH91068.1; -; mRNA.
DR   RefSeq; NP_001125618.1; NM_001132146.1.
DR   AlphaFoldDB; Q5RAZ2; -.
DR   BMRB; Q5RAZ2; -.
DR   SMR; Q5RAZ2; -.
DR   STRING; 9601.ENSPPYP00000019630; -.
DR   PRIDE; Q5RAZ2; -.
DR   Ensembl; ENSPPYT00000020402; ENSPPYP00000019630; ENSPPYG00000017513.
DR   GeneID; 100172536; -.
DR   KEGG; pon:100172536; -.
DR   CTD; 51119; -.
DR   eggNOG; KOG2917; Eukaryota.
DR   GeneTree; ENSGT00390000008135; -.
DR   HOGENOM; CLU_043216_1_1_1; -.
DR   InParanoid; Q5RAZ2; -.
DR   OMA; AVNPQMD; -.
DR   OrthoDB; 1217666at2759; -.
DR   TreeFam; TF300881; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0048539; P:bone marrow development; ISS:UniProtKB.
DR   GO; GO:0030282; P:bone mineralization; ISS:UniProtKB.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR   GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 1.10.10.900; -; 1.
DR   Gene3D; 3.30.1250.10; -; 1.
DR   InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR   InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR   InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR   InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR   InterPro; IPR002140; Sdo1/SBDS.
DR   InterPro; IPR039100; Sdo1/SBDS-like.
DR   InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR   PANTHER; PTHR10927; PTHR10927; 1.
DR   Pfam; PF01172; SBDS; 1.
DR   Pfam; PF09377; SBDS_C; 1.
DR   SUPFAM; SSF109728; SSF109728; 1.
DR   SUPFAM; SSF89895; SSF89895; 1.
DR   TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR   PROSITE; PS01267; UPF0023; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3A5"
FT   CHAIN           2..250
FT                   /note="Ribosome maturation protein SBDS"
FT                   /id="PRO_0000304732"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3A5"
SQ   SEQUENCE   250 AA;  28764 MW;  D35C43003C05F5A7 CRC64;
     MSIFTPTNQI RLTNVAVVRM KRAGKRFEIA CYKNKVVGWR SGVEKDLDEV LQTHSVFVNV
     SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER HTQLEQMFRD IATIVADKCV
     NPETKRPYTV ILIERAMKDI HYSVKTNKST KQQALEVIKQ LKEKMKIERA HMRLRFILPV
     NEGKKLKEKL KPLIKVIESE DYGQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLNLK
     DVEEGDEKFE