SBDS_RAT
ID SBDS_RAT Reviewed; 250 AA.
AC Q5RK30;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ribosome maturation protein SBDS;
DE AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN Name=Sbds;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC biogenesis. Together with EFL1, triggers the GTP-dependent release of
CC EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating
CC ribosomes for translation competence by allowing 80S ribosome assembly
CC and facilitating EIF6 recycling to the nucleus, where it is required
CC for 60S rRNA processing and nuclear export. Required for normal levels
CC of protein synthesis. May play a role in cellular stress resistance.
CC May play a role in cellular response to DNA damage. May play a role in
CC cell proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the 60S ribosomal subunit. Interacts with
CC NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex
CC consisting of 60S ribosomal subunit, SBDS and EFL1. Interacts with CLN3
CC (By similarity). {ECO:0000250|UniProtKB:Q9Y3A5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC cytoplasm, and at low levels in nucleus. Detected in the nucleolus
CC during G1 and G2 phase of the cell cycle, and diffusely distributed in
CC the nucleus during S phase. Detected at the mitotic spindle.
CC Colocalizes with the microtubule organizing center during interphase
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC086335; AAH86335.1; -; mRNA.
DR RefSeq; NP_001008290.1; NM_001008289.1.
DR AlphaFoldDB; Q5RK30; -.
DR BMRB; Q5RK30; -.
DR SMR; Q5RK30; -.
DR IntAct; Q5RK30; 1.
DR STRING; 10116.ENSRNOP00000001190; -.
DR iPTMnet; Q5RK30; -.
DR PhosphoSitePlus; Q5RK30; -.
DR jPOST; Q5RK30; -.
DR PaxDb; Q5RK30; -.
DR PRIDE; Q5RK30; -.
DR Ensembl; ENSRNOT00000107229; ENSRNOP00000093962; ENSRNOG00000000888.
DR GeneID; 288615; -.
DR KEGG; rno:288615; -.
DR CTD; 51119; -.
DR RGD; 1311043; Sbds.
DR eggNOG; KOG2917; Eukaryota.
DR GeneTree; ENSGT00390000008135; -.
DR HOGENOM; CLU_043216_1_1_1; -.
DR InParanoid; Q5RK30; -.
DR OMA; AVNPQMD; -.
DR OrthoDB; 1217666at2759; -.
DR PhylomeDB; Q5RK30; -.
DR TreeFam; TF300881; -.
DR PRO; PR:Q5RK30; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000000888; Expressed in lung and 20 other tissues.
DR Genevisible; Q5RK30; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISO:RGD.
DR GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; ISO:RGD.
DR GO; GO:0048539; P:bone marrow development; ISO:RGD.
DR GO; GO:0030282; P:bone mineralization; ISO:RGD.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
DR GO; GO:0001833; P:inner cell mass cell proliferation; ISO:RGD.
DR GO; GO:0030595; P:leukocyte chemotaxis; ISO:RGD.
DR GO; GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; ISO:RGD.
DR GO; GO:0006364; P:rRNA processing; ISO:RGD.
DR Gene3D; 1.10.10.900; -; 1.
DR Gene3D; 3.30.1250.10; -; 1.
DR InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR InterPro; IPR002140; Sdo1/SBDS.
DR InterPro; IPR039100; Sdo1/SBDS-like.
DR InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR PANTHER; PTHR10927; PTHR10927; 1.
DR Pfam; PF01172; SBDS; 1.
DR Pfam; PF09377; SBDS_C; 1.
DR SUPFAM; SSF109728; SSF109728; 1.
DR SUPFAM; SSF89895; SSF89895; 1.
DR TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR PROSITE; PS01267; UPF0023; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW Reference proteome; Ribosome biogenesis.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A5"
FT CHAIN 2..250
FT /note="Ribosome maturation protein SBDS"
FT /id="PRO_0000304733"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A5"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70122"
SQ SEQUENCE 250 AA; 28752 MW; 31339F6BB478740A CRC64;
MSIFTPTNQI RLTNVAVVRM KRGGKRFEIA CYKNKVVGWR SGVEKDLDEV LQTHSVFVNV
SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER HTQLEQMFRD IATIVADKCV
NPETKRPYTV ILIERAMKDI HYSVKPNKST KQQALEVIKQ LKEKMKIERA HMRLRFLLPV
NEGKKLKEKL KPLMKVVESE DYSQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLSLK
DVEEGDEKFE
