SBDS_XENLA
ID SBDS_XENLA Reviewed; 250 AA.
AC A5D8M6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Ribosome maturation protein SBDS;
DE AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN Name=sbds;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC biogenesis. Together with EFL1, triggers the GTP-dependent release of
CC eif6 from 60S pre-ribosomes in the cytoplasm, thereby activating
CC ribosomes for translation competence by allowing 80S ribosome assembly
CC and facilitating eif6 recycling to the nucleus, where it is required
CC for 60S rRNA processing and nuclear export. Required for normal levels
CC of protein synthesis. May play a role in cellular stress resistance.
CC May play a role in cellular response to DNA damage. May play a role in
CC cell proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the 60S ribosomal subunit. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC cytoplasm, and at low levels in nucleus and nucleolus. Detected at the
CC mitotic spindle. Colocalizes with the microtubule organizing center
CC during interphase (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR EMBL; BC141736; AAI41737.1; -; mRNA.
DR RefSeq; NP_001092159.1; NM_001098689.1.
DR AlphaFoldDB; A5D8M6; -.
DR SMR; A5D8M6; -.
DR MaxQB; A5D8M6; -.
DR DNASU; 100049749; -.
DR GeneID; 100049749; -.
DR KEGG; xla:100049749; -.
DR CTD; 100049749; -.
DR Xenbase; XB-GENE-1003512; sbds.S.
DR OrthoDB; 1217666at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 100049749; Expressed in testis and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
DR GO; GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
DR Gene3D; 1.10.10.900; -; 1.
DR Gene3D; 3.30.1250.10; -; 1.
DR InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR InterPro; IPR002140; Sdo1/SBDS.
DR InterPro; IPR039100; Sdo1/SBDS-like.
DR InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR PANTHER; PTHR10927; PTHR10927; 1.
DR Pfam; PF01172; SBDS; 1.
DR Pfam; PF09377; SBDS_C; 1.
DR SUPFAM; SSF109728; SSF109728; 1.
DR SUPFAM; SSF89895; SSF89895; 1.
DR TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR PROSITE; PS01267; UPF0023; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..250
FT /note="Ribosome maturation protein SBDS"
FT /id="PRO_0000304735"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 250 AA; 28709 MW; DA1B20C36BB88494 CRC64;
MSIFTPTNQI RLTNVAVVRM KKGGKRFEIA CYKNKVMSWR SGAEKDLDEV LQTHSVFMNV
SKGQGAKKED LLKAFGTEDQ TEICKQILSK GELQVSEKER STQLEQMFRD IATIVADKCV
NPETKRPYTV NLIERAMKDI HYSVKATKST KQQALDVIKQ LKETMQIERA HMRLRFIVPA
KDGKKLKEKL KPLIKHIESE NFDQELEIVC LIDPGCFREI DELIRCETKG KGTLEVLSLK
DVEEGDEKFE