ID   SBDS_XENTR              Reviewed;         250 AA.
AC   Q6DIT8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Ribosome maturation protein SBDS;
DE   AltName: Full=Shwachman-Bodian-Diamond syndrome protein homolog;
GN   Name=sbds; ORFNames=TGas062n22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of mature ribosomes and ribosome
CC       biogenesis. Together with EFL1, triggers the GTP-dependent release of
CC       eif6 from 60S pre-ribosomes in the cytoplasm, thereby activating
CC       ribosomes for translation competence by allowing 80S ribosome assembly
CC       and facilitating eif6 recycling to the nucleus, where it is required
CC       for 60S rRNA processing and nuclear export. Required for normal levels
CC       of protein synthesis. May play a role in cellular stress resistance.
CC       May play a role in cellular response to DNA damage. May play a role in
CC       cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the 60S ribosomal subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the
CC       cytoplasm, and at low levels in nucleus and nucleolus. Detected at the
CC       mitotic spindle. Colocalizes with the microtubule organizing center
CC       during interphase (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDO1/SBDS family. {ECO:0000305}.
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DR   EMBL; CR855635; CAJ83828.1; -; mRNA.
DR   EMBL; BC075447; AAH75447.1; -; mRNA.
DR   RefSeq; NP_001004953.1; NM_001004953.1.
DR   AlphaFoldDB; Q6DIT8; -.
DR   SMR; Q6DIT8; -.
DR   STRING; 8364.ENSXETP00000013630; -.
DR   PaxDb; Q6DIT8; -.
DR   DNASU; 448365; -.
DR   GeneID; 448365; -.
DR   KEGG; xtr:448365; -.
DR   CTD; 51119; -.
DR   Xenbase; XB-GENE-1003506; sbds.
DR   eggNOG; KOG2917; Eukaryota.
DR   HOGENOM; CLU_043216_1_1_1; -.
DR   InParanoid; Q6DIT8; -.
DR   OrthoDB; 1217666at2759; -.
DR   PhylomeDB; Q6DIT8; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q6DIT8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
DR   Gene3D; 1.10.10.900; -; 1.
DR   Gene3D; 3.30.1250.10; -; 1.
DR   InterPro; IPR018023; Ribosome_mat_SBDS_CS.
DR   InterPro; IPR036786; Ribosome_mat_SBDS_N_sf.
DR   InterPro; IPR018978; Ribosome_mat_Sdo1/SBDS_C.
DR   InterPro; IPR019783; Ribosome_mat_Sdo1/SBDS_N.
DR   InterPro; IPR002140; Sdo1/SBDS.
DR   InterPro; IPR039100; Sdo1/SBDS-like.
DR   InterPro; IPR037188; Sdo1/SBDS_central_sf.
DR   PANTHER; PTHR10927; PTHR10927; 1.
DR   Pfam; PF01172; SBDS; 1.
DR   Pfam; PF09377; SBDS_C; 1.
DR   SUPFAM; SSF109728; SSF109728; 1.
DR   SUPFAM; SSF89895; SSF89895; 1.
DR   TIGRFAMs; TIGR00291; RNA_SBDS; 1.
DR   PROSITE; PS01267; UPF0023; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..250
FT                   /note="Ribosome maturation protein SBDS"
FT                   /id="PRO_0000304736"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   250 AA;  28738 MW;  9D75A5C232D269BA CRC64;
     MSIFTPTNQI RLTNVAVVRM KKGGKRFEIA CYKNKVMSWR SGAEKDLDEV LQTHSVFMNV
     SKGQVAKKED LLKSFGTEDP TEICKQILSK GELQVSEKER STQLEQMFRD IATIVADKCV
     NPETKRPYTV NLIERAMKDI HYSVKATKST KQQALDVIKQ LKETMQIERA HMRLRFILPA
     KDGKKLKEKL KPLIKHTESE NFDQELEIVC LIDPGCFREI DELIRCETKG KGTLEVLSLK
     DVEEGDEKFE