ID   SBE2_KLULA              Reviewed;         821 AA.
AC   Q6CMA8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Protein SBE2;
GN   Name=SBE2; OrderedLocusNames=KLLA0E21758g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: With SBE22, is involved in cell wall integrity and polarity
CC       processes like bud growth. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SBE2 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAH00018.1; -; Genomic_DNA.
DR   RefSeq; XP_454931.1; XM_454931.1.
DR   AlphaFoldDB; Q6CMA8; -.
DR   STRING; 28985.XP_454931.1; -.
DR   EnsemblFungi; CAH00018; CAH00018; KLLA0_E21671g.
DR   GeneID; 2894611; -.
DR   KEGG; kla:KLLA0_E21671g; -.
DR   eggNOG; ENOG502QR4N; Eukaryota.
DR   HOGENOM; CLU_019068_0_0_1; -.
DR   InParanoid; Q6CMA8; -.
DR   OMA; SSTRPIW; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031505; P:fungal-type cell wall organization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031403; Sbe2/Sbe22.
DR   Pfam; PF17076; SBE2; 2.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Golgi apparatus; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..821
FT                   /note="Protein SBE2"
FT                   /id="PRO_0000320505"
FT   REGION          1..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  93287 MW;  23F6CE71DFCCAB6C CRC64;
     MVAARPRKAG TYPTTAQVPS SANASSISSY TNSSNSKTVG SGITRRPSEN MLLNMAEGKQ
     SQNQNQQQQQ QQHQTHNPRS SANGSEESDH VLSFKPPNRK AVLIKNERPI SNDSINTEGD
     VFSINAGSSK DSSRGTSIID DDDDENHDTE QSAVLDGKVS ANVMPRGKKS FSSVKQNPVT
     PHSSVTDGLD DVSHLTDTSF SDADLSVTTV KVASAPKSMN TKYIFNNPGS QGKSVAPDAF
     QSVDSSPKLT RSMFSTVNPT AMHSSYDQHS QLHGQSQPLH NTHPLATSLH SKSVPALPSD
     SLNGKKPLTP SQRYRLRREQ NKLHLQHSIK QKELFYDEDA KLPANDLLDE SLVWSIPTAS
     HSSTFISQRK HRASVPNVGR SAKLLDGHDM PPSPIPGVQK VSDLEYFQQV GKNLSAVYQK
     SEYEVTKSKL LERTQSAELL PLDFKNASVE GMEDLKLVSD DKVSIISSTR PCWLPPKDTE
     ERRSHERDVR KTLSMASIEK LETNQRRHEQ EIKNETNNQK LVLLIDRGLN RKSSLQDLKK
     IAWETGFSSA RRSFIYNTVL NTDFNIISTK YMDDTSSLDN IIRSKMTPFP STQMAEINKL
     VDDMHFPVES QIRSKLIKLL QWKSISRFGL QTGDNYLMLH FLLEGYDLEL IWKLANLLQL
     TCFNSITRDK YDNRIMNRDG VVGRYMRKDS AFAEEFDSRY LNYMTFWNCL ARVDHDLFIW
     IMDIIVAENA RASRWTEEWQ HQLRNTDWDT FKEKYIVVNY KVLCSLSLNV LLRYHFGWNN
     LLHLDELPPS FQLVKPVDNR EPVSDQYLVF IKKWNHYYAK F