SBK1_HUMAN
ID SBK1_HUMAN Reviewed; 424 AA.
AC Q52WX2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Serine/threonine-protein kinase SBK1;
DE EC=2.7.11.1;
DE AltName: Full=SH3-binding kinase 1;
GN Name=SBK1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang P.Z., Wang X., Wang F., Wu J.;
RT "Cloning of human SBK1 cDNA and screening of its interaction proteins.";
RL Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 22:313-321(2006).
RN [2]
RP VARIANTS [LARGE SCALE ANALYSIS] GLU-92; THR-250 AND SER-261.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
CC -!- FUNCTION: May be involved in signal-transduction pathways related to
CC the control of brain development. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AY874862; AAX59898.1; -; mRNA.
DR CCDS; CCDS32416.1; -.
DR RefSeq; NP_001019572.1; NM_001024401.2.
DR AlphaFoldDB; Q52WX2; -.
DR SMR; Q52WX2; -.
DR BioGRID; 132609; 35.
DR STRING; 9606.ENSP00000343248; -.
DR BindingDB; Q52WX2; -.
DR ChEMBL; CHEMBL1163129; -.
DR DrugBank; DB12010; Fostamatinib.
DR DrugCentral; Q52WX2; -.
DR iPTMnet; Q52WX2; -.
DR PhosphoSitePlus; Q52WX2; -.
DR BioMuta; SBK1; -.
DR DMDM; 74762155; -.
DR MassIVE; Q52WX2; -.
DR PaxDb; Q52WX2; -.
DR PeptideAtlas; Q52WX2; -.
DR PRIDE; Q52WX2; -.
DR ProteomicsDB; 62433; -.
DR Antibodypedia; 55882; 22 antibodies from 13 providers.
DR DNASU; 388228; -.
DR Ensembl; ENST00000341901.5; ENSP00000343248.4; ENSG00000188322.8.
DR GeneID; 388228; -.
DR KEGG; hsa:388228; -.
DR MANE-Select; ENST00000341901.5; ENSP00000343248.4; NM_001024401.3; NP_001019572.1.
DR UCSC; uc002dpd.3; human.
DR CTD; 388228; -.
DR DisGeNET; 388228; -.
DR GeneCards; SBK1; -.
DR HGNC; HGNC:17699; SBK1.
DR HPA; ENSG00000188322; Tissue enhanced (brain, skeletal muscle).
DR neXtProt; NX_Q52WX2; -.
DR OpenTargets; ENSG00000188322; -.
DR PharmGKB; PA134887617; -.
DR VEuPathDB; HostDB:ENSG00000188322; -.
DR eggNOG; KOG1345; Eukaryota.
DR GeneTree; ENSGT00940000154852; -.
DR HOGENOM; CLU_000288_10_1_1; -.
DR InParanoid; Q52WX2; -.
DR OMA; IFCFIKY; -.
DR OrthoDB; 1221624at2759; -.
DR PhylomeDB; Q52WX2; -.
DR TreeFam; TF326736; -.
DR PathwayCommons; Q52WX2; -.
DR SignaLink; Q52WX2; -.
DR BioGRID-ORCS; 388228; 13 hits in 1101 CRISPR screens.
DR ChiTaRS; SBK1; human.
DR GenomeRNAi; 388228; -.
DR Pharos; Q52WX2; Tchem.
DR PRO; PR:Q52WX2; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q52WX2; protein.
DR Bgee; ENSG00000188322; Expressed in cortical plate and 152 other tissues.
DR ExpressionAtlas; Q52WX2; baseline and differential.
DR Genevisible; Q52WX2; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0018107; P:peptidyl-threonine phosphorylation; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR016234; Ser/Thr_kinase_Sbk1.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF000566; Ser/Thr_PK_Sbk1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..424
FT /note="Serine/threonine-protein kinase SBK1"
FT /id="PRO_0000238451"
FT DOMAIN 53..318
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 321..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 174
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 59..67
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 82
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT VARIANT 12
FT /note="R -> H (in dbSNP:rs35448675)"
FT /id="VAR_051665"
FT VARIANT 92
FT /note="K -> E (in an ovarian mucinous carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041068"
FT VARIANT 250
FT /note="N -> T (in dbSNP:rs56072383)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041069"
FT VARIANT 261
FT /note="A -> S"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041070"
SQ SEQUENCE 424 AA; 46252 MW; 2E07FFDA5693311F CRC64;
MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG
KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET
EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV
LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG
VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG
SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI
EICV
