SBK3_HUMAN
ID SBK3_HUMAN Reviewed; 359 AA.
AC P0C264;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Uncharacterized serine/threonine-protein kinase SBK3;
DE EC=2.7.11.1;
DE AltName: Full=SH3-binding domain kinase family member 3;
DE AltName: Full=Sugen kinase 110;
GN Name=SBK3; Synonyms=SGK110;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=12471243; DOI=10.1126/science.1075762;
RA Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.;
RT "The protein kinase complement of the human genome.";
RL Science 298:1912-1934(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INTERACTION:
CC P0C264; Q13155: AIMP2; NbExp=3; IntAct=EBI-17181801, EBI-745226;
CC P0C264; O95561: C1orf105; NbExp=3; IntAct=EBI-17181801, EBI-10191951;
CC P0C264; Q49AN0: CRY2; NbExp=3; IntAct=EBI-17181801, EBI-2212355;
CC P0C264; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-17181801, EBI-399105;
CC P0C264; Q13868: EXOSC2; NbExp=3; IntAct=EBI-17181801, EBI-301735;
CC P0C264; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-17181801, EBI-923440;
CC P0C264; Q8NHZ7: MBD3L2; NbExp=3; IntAct=EBI-17181801, EBI-11989378;
CC P0C264; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-17181801, EBI-17490746;
CC P0C264; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-17181801, EBI-10276663;
CC P0C264; P84022: SMAD3; NbExp=3; IntAct=EBI-17181801, EBI-347161;
CC P0C264; Q16560-2: SNRNP35; NbExp=3; IntAct=EBI-17181801, EBI-12938570;
CC P0C264; P13805-3: TNNT1; NbExp=3; IntAct=EBI-17181801, EBI-12151635;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. STKL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AC008735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS74457.1; -.
DR RefSeq; NP_001186753.1; NM_001199824.2.
DR AlphaFoldDB; P0C264; -.
DR SMR; P0C264; -.
DR BioGRID; 934928; 13.
DR IntAct; P0C264; 12.
DR STRING; 9606.ENSP00000483467; -.
DR BindingDB; P0C264; -.
DR ChEMBL; CHEMBL5116; -.
DR DrugBank; DB12010; Fostamatinib.
DR DrugCentral; P0C264; -.
DR iPTMnet; P0C264; -.
DR PhosphoSitePlus; P0C264; -.
DR BioMuta; SBK3; -.
DR DMDM; 161783904; -.
DR jPOST; P0C264; -.
DR MassIVE; P0C264; -.
DR PaxDb; P0C264; -.
DR PeptideAtlas; P0C264; -.
DR PRIDE; P0C264; -.
DR Antibodypedia; 70937; 19 antibodies from 7 providers.
DR DNASU; 100130827; -.
DR Ensembl; ENST00000612221.1; ENSP00000483467.1; ENSG00000231274.5.
DR GeneID; 100130827; -.
DR KEGG; hsa:100130827; -.
DR MANE-Select; ENST00000612221.1; ENSP00000483467.1; NM_001199824.2; NP_001186753.1.
DR UCSC; uc032ifx.1; human.
DR CTD; 100130827; -.
DR GeneCards; SBK3; -.
DR HGNC; HGNC:44121; SBK3.
DR HPA; ENSG00000231274; Tissue enhanced (heart muscle, tongue).
DR neXtProt; NX_P0C264; -.
DR OpenTargets; ENSG00000231274; -.
DR VEuPathDB; HostDB:ENSG00000231274; -.
DR eggNOG; KOG1345; Eukaryota.
DR GeneTree; ENSGT00940000154852; -.
DR HOGENOM; CLU_000288_10_0_1; -.
DR InParanoid; P0C264; -.
DR OMA; RPPPPWD; -.
DR OrthoDB; 1221624at2759; -.
DR PhylomeDB; P0C264; -.
DR PathwayCommons; P0C264; -.
DR SignaLink; P0C264; -.
DR BioGRID-ORCS; 100130827; 8 hits in 267 CRISPR screens.
DR GenomeRNAi; 100130827; -.
DR Pharos; P0C264; Tchem.
DR PRO; PR:P0C264; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P0C264; protein.
DR Bgee; ENSG00000231274; Expressed in right atrium auricular region and 66 other tissues.
DR ExpressionAtlas; P0C264; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..359
FT /note="Uncharacterized serine/threonine-protein kinase
FT SBK3"
FT /id="PRO_0000262995"
FT DOMAIN 43..309
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 314..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 163
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 49..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 72
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 359 AA; 38488 MW; 3E6AFF74412256C9 CRC64;
MERRASETPE DGDPEEDTAT ALQRLVELTT SRVTPVRSLR DQYHLIRKLG SGSYGRVLLA
QPHQGGPAVA LKLLRRDLVL RSTFLREFCV GRCVSAHPGL LQTLAGPLQT PRYFAFAQEY
APCGDLSGML QERGLPELLV KRVVAQLAGA LDFLHSRGLV HADVKPDNVL VFDPVCSRVA
LGDLGLTRPE GSPTPAPPVP LPTAPPELCL LLPPDTLPLR PAVDSWGLGV LLFCAATACF
PWDVALAPNP EFEAFAGWVT TKPQPPQPPP PWDQFAPPAL ALLQGLLDLD PETRSPPLAV
LDFLGDDWGL QGNREGPGVL GSAVSYEDRE EGGSSLEEWT DEGDDSKSGG RTGTDGGAP
