SBK3_MOUSE
ID SBK3_MOUSE Reviewed; 361 AA.
AC P0C5K0; D3Z5J0; E9QLM1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-DEC-2013, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Uncharacterized serine/threonine-protein kinase SBK3;
DE EC=2.7.11.1;
DE AltName: Full=SH3-binding domain kinase family member 3;
DE AltName: Full=Sugen kinase 110;
GN Name=Sbk3; Synonyms=Gm1078, Sgk110;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0C5K0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0C5K0-2; Sequence=VSP_053507;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. STKL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AC157563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS57475.1; -. [P0C5K0-2]
DR RefSeq; NP_001186970.1; NM_001200041.1. [P0C5K0-2]
DR RefSeq; XP_006540196.1; XM_006540133.3. [P0C5K0-1]
DR RefSeq; XP_006540197.1; XM_006540134.3.
DR RefSeq; XP_006540198.1; XM_006540135.3. [P0C5K0-2]
DR RefSeq; XP_006540200.1; XM_006540137.3.
DR AlphaFoldDB; P0C5K0; -.
DR SMR; P0C5K0; -.
DR STRING; 10090.ENSMUSP00000122507; -.
DR iPTMnet; P0C5K0; -.
DR PhosphoSitePlus; P0C5K0; -.
DR PaxDb; P0C5K0; -.
DR PRIDE; P0C5K0; -.
DR ProteomicsDB; 256923; -. [P0C5K0-1]
DR ProteomicsDB; 256924; -. [P0C5K0-2]
DR Antibodypedia; 70937; 19 antibodies from 7 providers.
DR DNASU; 381835; -.
DR Ensembl; ENSMUST00000133272; ENSMUSP00000120654; ENSMUSG00000085272. [P0C5K0-1]
DR Ensembl; ENSMUST00000144863; ENSMUSP00000122507; ENSMUSG00000085272. [P0C5K0-2]
DR GeneID; 381835; -.
DR KEGG; mmu:381835; -.
DR UCSC; uc009ezb.1; mouse. [P0C5K0-1]
DR CTD; 100130827; -.
DR MGI; MGI:2685924; Sbk3.
DR VEuPathDB; HostDB:ENSMUSG00000085272; -.
DR eggNOG; KOG1345; Eukaryota.
DR GeneTree; ENSGT00940000154852; -.
DR HOGENOM; CLU_000288_10_0_1; -.
DR InParanoid; P0C5K0; -.
DR OMA; RPPPPWD; -.
DR OrthoDB; 1221624at2759; -.
DR PhylomeDB; P0C5K0; -.
DR TreeFam; TF326736; -.
DR BioGRID-ORCS; 381835; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Sbk3; mouse.
DR PRO; PR:P0C5K0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P0C5K0; protein.
DR Bgee; ENSMUSG00000085272; Expressed in secondary oocyte and 26 other tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Kinase; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..361
FT /note="Uncharacterized serine/threonine-protein kinase
FT SBK3"
FT /id="PRO_0000308263"
FT DOMAIN 43..309
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 312..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..351
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 163
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 49..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 72
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT VAR_SEQ 1..19
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_053507"
SQ SEQUENCE 361 AA; 39117 MW; 282A8AEC143E3949 CRC64;
MERRVLETTE DGDTEEDTAM ALQRLVELTA SRVTSVRSLC VQYRLIRKLG SGSYGRVLLA
QPRQGGQTVA LKLLRRDSVL RTTFLREFCV GRCVSSHPGL LQTLGRPLQT PRYFAFAQEF
APCGDLSGML QEKGLPELMV KRIVAQLAGA LDFLHGRGLV HADVKPDNVL VFDPDCNRVA
LGDLGLTRPE GSPTPAPPVP LPTAPPELCL LLPPNTLPLR PAVDSWALGV LLFCAATACF
PWDVALAPDP EFEAFAGWMT TKPQPPRPPA PWDQFAPPAL TLLQGLLDLD PETRSPPLAV
FDVLGDNWGL QGSGEGSGSL GVIPYKDGEE EEGGSSLEEW TDEEEDEIKD SGGMEADNRA
S
