ID   SBMC2_DICD3             Reviewed;         157 AA.
AC   E0SBQ8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=DNA gyrase inhibitor 2 {ECO:0000255|HAMAP-Rule:MF_01896};
GN   Name=sbmC2 {ECO:0000255|HAMAP-Rule:MF_01896};
GN   OrderedLocusNames=Dda3937_01484;
OS   Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=198628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=21217001; DOI=10.1128/jb.01513-10;
RA   Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA   Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA   Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA   Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA   Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA   Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA   Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA   Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA   Blattner F.R., Keen N.T., Perna N.T.;
RT   "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL   J. Bacteriol. 193:2076-2077(2011).
CC   -!- FUNCTION: Inhibits the supercoiling activity of DNA gyrase. Acts by
CC       inhibiting DNA gyrase at an early step, prior to (or at the step of)
CC       binding of DNA by the gyrase. It protects cells against toxins that
CC       target DNA gyrase, by inhibiting activity of these toxins and reducing
CC       the formation of lethal double-strand breaks in the cell.
CC       {ECO:0000255|HAMAP-Rule:MF_01896}.
CC   -!- SUBUNIT: Interacts with DNA gyrase. {ECO:0000255|HAMAP-Rule:MF_01896}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01896}.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor family.
CC       {ECO:0000255|HAMAP-Rule:MF_01896}.
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DR   EMBL; CP002038; ADM97206.1; -; Genomic_DNA.
DR   RefSeq; WP_013316679.1; NC_014500.1.
DR   AlphaFoldDB; E0SBQ8; -.
DR   SMR; E0SBQ8; -.
DR   STRING; 198628.Dda3937_01484; -.
DR   EnsemblBacteria; ADM97206; ADM97206; Dda3937_01484.
DR   GeneID; 9732408; -.
DR   KEGG; ddd:Dda3937_01484; -.
DR   PATRIC; fig|198628.6.peg.1009; -.
DR   eggNOG; COG3449; Bacteria.
DR   HOGENOM; CLU_113664_3_2_6; -.
DR   OMA; ACFEHYL; -.
DR   OrthoDB; 1748122at2; -.
DR   BioCyc; DDAD198628:DDA3937_RS04780-MON; -.
DR   Proteomes; UP000006859; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2000372; P:negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.80.10; -; 1.
DR   HAMAP; MF_01896; DNA_gyrase_inhibitor; 1.
DR   InterPro; IPR010499; AraC_E-bd.
DR   InterPro; IPR024911; DNA_gyrase_inhibitor_GyrI.
DR   InterPro; IPR029442; GyrI-like.
DR   InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR   Pfam; PF06445; GyrI-like; 1.
DR   SMART; SM00871; AraC_E_bind; 1.
DR   SUPFAM; SSF55136; SSF55136; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..157
FT                   /note="DNA gyrase inhibitor 2"
FT                   /id="PRO_0000409694"
SQ   SEQUENCE   157 AA;  17599 MW;  60FC91CCCCE9F668 CRC64;
     MTLRFDVAPP KKVHCLRVIG PYYQSVPDGF QKLMAWSQEQ QLPWTETLAF YWDDPSETEQ
     DQLRADVALV LPEGTAIGEN TLGVREETVP GGLFAVLHTI VSNGEFAKAW NELYDLIAQN
     GYKPARGICF ESYLCDGSSG NWEIEIWQSV DPNDGAQ