SBMC_EDWTE
ID SBMC_EDWTE Reviewed; 155 AA.
AC D0ZEW7;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=DNA gyrase inhibitor {ECO:0000255|HAMAP-Rule:MF_01896};
GN Name=sbmC {ECO:0000255|HAMAP-Rule:MF_01896}; OrderedLocusNames=ETAE_1076;
OS Edwardsiella tarda (strain EIB202).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Edwardsiella.
OX NCBI_TaxID=498217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EIB202;
RX PubMed=19865481; DOI=10.1371/journal.pone.0007646;
RA Wang Q., Yang M., Xiao J., Wu H., Wang X., Lv Y., Xu L., Zheng H., Wang S.,
RA Zhao G., Liu Q., Zhang Y.;
RT "Genome sequence of the versatile fish pathogen Edwardsiella tarda provides
RT insights into its adaptation to broad host ranges and intracellular
RT niches.";
RL PLoS ONE 4:E7646-E7646(2009).
CC -!- FUNCTION: Inhibits the supercoiling activity of DNA gyrase. Acts by
CC inhibiting DNA gyrase at an early step, prior to (or at the step of)
CC binding of DNA by the gyrase. It protects cells against toxins that
CC target DNA gyrase, by inhibiting activity of these toxins and reducing
CC the formation of lethal double-strand breaks in the cell.
CC {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SUBUNIT: Interacts with DNA gyrase. {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SIMILARITY: Belongs to the DNA gyrase inhibitor family.
CC {ECO:0000255|HAMAP-Rule:MF_01896}.
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DR EMBL; CP001135; ACY83921.1; -; Genomic_DNA.
DR RefSeq; WP_012847940.1; NC_013508.1.
DR AlphaFoldDB; D0ZEW7; -.
DR SMR; D0ZEW7; -.
DR EnsemblBacteria; ACY83921; ACY83921; ETAE_1076.
DR KEGG; etr:ETAE_1076; -.
DR HOGENOM; CLU_113664_3_2_6; -.
DR OMA; TPWYQFF; -.
DR OrthoDB; 1748122at2; -.
DR Proteomes; UP000002634; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:2000372; P:negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.80.10; -; 1.
DR HAMAP; MF_01896; DNA_gyrase_inhibitor; 1.
DR InterPro; IPR010499; AraC_E-bd.
DR InterPro; IPR024911; DNA_gyrase_inhibitor_GyrI.
DR InterPro; IPR029442; GyrI-like.
DR InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR Pfam; PF06445; GyrI-like; 1.
DR SMART; SM00871; AraC_E_bind; 1.
DR SUPFAM; SSF55136; SSF55136; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Stress response.
FT CHAIN 1..155
FT /note="DNA gyrase inhibitor"
FT /id="PRO_0000409696"
SQ SEQUENCE 155 AA; 16868 MW; A78E9746678FAE2E CRC64;
MQVKIESLAA QPLFALRVQG PFAQSLGPGF ERLMAWSTRH GLQGQWMALY YDNPREVAPE
ALRADVALTT ATTALPSDGE ASGIRWDTLA GGLYALAQVR VIDNDFATPW VALFDQALPA
SGYRPDGGPC FERYLSDGRA SGEWLLELGV PVRKS