SBMC_SALTI
ID SBMC_SALTI Reviewed; 155 AA.
AC P0A213; P41781;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=DNA gyrase inhibitor {ECO:0000255|HAMAP-Rule:MF_01896};
GN Name=sbmC {ECO:0000255|HAMAP-Rule:MF_01896}; Synonyms=gyrI;
GN OrderedLocusNames=STY2266, t0813;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Inhibits the supercoiling activity of DNA gyrase. Acts by
CC inhibiting DNA gyrase at an early step, prior to (or at the step of)
CC binding of DNA by the gyrase. It protects cells against toxins that
CC target DNA gyrase, by inhibiting activity of these toxins and reducing
CC the formation of lethal double-strand breaks in the cell.
CC {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SUBUNIT: Interacts with DNA gyrase. {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01896}.
CC -!- SIMILARITY: Belongs to the DNA gyrase inhibitor family.
CC {ECO:0000255|HAMAP-Rule:MF_01896}.
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DR EMBL; AL513382; CAD02422.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68502.1; -; Genomic_DNA.
DR RefSeq; NP_456610.1; NC_003198.1.
DR RefSeq; WP_000384326.1; NZ_WSUR01000002.1.
DR AlphaFoldDB; P0A213; -.
DR SMR; P0A213; -.
DR STRING; 220341.16503291; -.
DR EnsemblBacteria; AAO68502; AAO68502; t0813.
DR KEGG; stt:t0813; -.
DR KEGG; sty:STY2266; -.
DR PATRIC; fig|220341.7.peg.2285; -.
DR eggNOG; COG3449; Bacteria.
DR HOGENOM; CLU_113664_3_2_6; -.
DR OMA; TPWYQFF; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:2000372; P:negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.80.10; -; 1.
DR HAMAP; MF_01896; DNA_gyrase_inhibitor; 1.
DR InterPro; IPR010499; AraC_E-bd.
DR InterPro; IPR024911; DNA_gyrase_inhibitor_GyrI.
DR InterPro; IPR029442; GyrI-like.
DR InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR Pfam; PF06445; GyrI-like; 1.
DR SMART; SM00871; AraC_E_bind; 1.
DR SUPFAM; SSF55136; SSF55136; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Stress response.
FT CHAIN 1..155
FT /note="DNA gyrase inhibitor"
FT /id="PRO_0000083883"
SQ SEQUENCE 155 AA; 18062 MW; FA14963A5EFE1DFD CRC64;
MDYEIRQEQK RKIAGFHMVG PWEHTVKQGF EQLMTWVDRQ RIVPVEWIAV YYDNPDVVPA
EKLRCDTVVS VAENFILPDN SEGVIVTAIE GGEYATAVAR VEDRDFAKPW ERFFDVLEQD
SAYQIASAPC FETYLNNGME DGYWDIEMYI PVQRK