ID   SBND_STAA8              Reviewed;         418 AA.
AC   Q2G1N0; Q6X7U4;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Staphyloferrin B transporter {ECO:0000305};
GN   Name=sbnD {ECO:0000303|PubMed:25680529};
GN   OrderedLocusNames=SAOUHSC_00078 {ECO:0000312|EMBL:ABD29261.1};
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX   PubMed=14688077; DOI=10.1128/iai.72.1.29-37.2004;
RA   Dale S.E., Doherty-Kirby A., Lajoie G., Heinrichs D.E.;
RT   "Role of siderophore biosynthesis in virulence of Staphylococcus aureus:
RT   identification and characterization of genes involved in production of a
RT   siderophore.";
RL   Infect. Immun. 72:29-37(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25680529; DOI=10.1016/j.febslet.2015.02.002;
RA   Hannauer M., Sheldon J.R., Heinrichs D.E.;
RT   "Involvement of major facilitator superfamily proteins SfaA and SbnD in
RT   staphyloferrin secretion in Staphylococcus aureus.";
RL   FEBS Lett. 589:730-737(2015).
CC   -!- FUNCTION: Involved in staphyloferrin B secretion.
CC       {ECO:0000269|PubMed:25680529}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Up-regulated under iron-deficient growth conditions.
CC       Repressed by Fur under iron-rich growth conditions.
CC       {ECO:0000269|PubMed:14688077}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene impacts growth in iron-
CC       depleted media. Mutant is partially impaired for staphyloferrin B
CC       secretion. {ECO:0000269|PubMed:25680529}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY251022; AAP82066.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD29261.1; -; Genomic_DNA.
DR   RefSeq; WP_000610051.1; NZ_LS483365.1.
DR   RefSeq; YP_498678.1; NC_007795.1.
DR   AlphaFoldDB; Q2G1N0; -.
DR   SMR; Q2G1N0; -.
DR   STRING; 1280.SAXN108_0105; -.
DR   TCDB; 2.A.1.2.99; the major facilitator superfamily (mfs).
DR   EnsemblBacteria; ABD29261; ABD29261; SAOUHSC_00078.
DR   EnsemblBacteria; GBV19676; GBV19676; M1K003_0649.
DR   EnsemblBacteria; KXA40237; KXA40237; HMPREF3211_00222.
DR   EnsemblBacteria; SCT50266; SCT50266; SAMEA1708674_03222.
DR   EnsemblBacteria; SUL30544; SUL30544; NCTC10702_00267.
DR   GeneID; 3919456; -.
DR   KEGG; sao:SAOUHSC_00078; -.
DR   PATRIC; fig|1280.10341.peg.115; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_57_5_9; -.
DR   OMA; VIRHNVP; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..418
FT                   /note="Staphyloferrin B transporter"
FT                   /id="PRO_0000447123"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   418 AA;  44835 MW;  7A17CE7BFA696D4D CRC64;
     MINQSIWRSN FRILWLSQFI AIAGLTVLVP LLPIYMASLQ NLSVVEIQLW SGIAIAAPAV
     TTMIASPIWG KLGDKISRKW MVLRALLGLA VCLFLMALCT TPLQFVLVRL LQGLFGGVVD
     ASSAFASAEA PAEDRGKVLG RLQSSVSAGS LVGPLIGGVT ASILGFSALL MSIAVITFIV
     CIFGALKLIE TTHMPKSQTP NINKGIRRSF QCLLCTQQTC RFIIVGVLAN FAMYGMLTAL
     SPLASSVNHT AIDDRSVIGF LQSAFWTASI LSAPLWGRFN DKSYVKSVYI FATIACGCSA
     ILQGLATNIE FLMAARILQG LTYSALIQSV MFVVVNACHQ QLKGTFVGTT NSMLVVGQII
     GSLSGAAITS YTTPATTFIV MGVVFAVSSL FLICSTITNQ INDHTLMKLW ELKQKSAK