SBNO1_MOUSE
ID SBNO1_MOUSE Reviewed; 1390 AA.
AC Q689Z5; Q3KQK3; Q8BVN5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein strawberry notch homolog 1;
DE Short=mSno1;
GN Name=Sbno1; Synonyms=Sno1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=17045962; DOI=10.1016/j.bbrc.2006.09.135;
RA Baba K., Dekimoto H., Muraoka D., Agata K., Terashima T., Katsuyama Y.;
RT "A mouse homologue of strawberry notch is transcriptionally regulated by
RT reelin signal.";
RL Biochem. Biophys. Res. Commun. 350:842-849(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-784 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Eye, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-716 (ISOFORM 2).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 790-809, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-690; SER-691; SER-695;
RP SER-765 AND SER-791, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q689Z5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q689Z5-2; Sequence=VSP_030299;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and testis. Expressed in
CC the hippocampus, olfactory bulb, and cerebellum. Low expression
CC detected in lung, heart, liver, skin, colon and kidney.
CC {ECO:0000269|PubMed:17045962}.
CC -!- DEVELOPMENTAL STAGE: At 11 dpc expressed throughout the entire
CC neuroepithelium. In the developing brain, expressed in the forebrain,
CC tectum, cerebellum, striatum and olfactory bulb. At 15.5 dpc expressed
CC in the cortex; the dorsal part of the telencephalon becomes laminated,
CC and expression is observed in the upper and ventricular layers. At 18.5
CC dpc expression in the ventricular zone is weak.
CC {ECO:0000269|PubMed:17045962}.
CC -!- MISCELLANEOUS: Expression is down-regulated in Reln-null embryos.
CC Expression in P19 cell line was up-regulated by treatment with Reln.
CC -!- SIMILARITY: Belongs to the SBNO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI06157.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AB188811; BAD38625.1; -; mRNA.
DR EMBL; AK077133; BAC36636.1; -; mRNA.
DR EMBL; BC106156; AAI06157.1; ALT_SEQ; mRNA.
DR CCDS; CCDS39280.1; -. [Q689Z5-2]
DR AlphaFoldDB; Q689Z5; -.
DR IntAct; Q689Z5; 1.
DR STRING; 10090.ENSMUSP00000066808; -.
DR iPTMnet; Q689Z5; -.
DR PhosphoSitePlus; Q689Z5; -.
DR EPD; Q689Z5; -.
DR jPOST; Q689Z5; -.
DR MaxQB; Q689Z5; -.
DR PaxDb; Q689Z5; -.
DR PRIDE; Q689Z5; -.
DR ProteomicsDB; 253399; -. [Q689Z5-1]
DR ProteomicsDB; 253400; -. [Q689Z5-2]
DR UCSC; uc008zpr.2; mouse. [Q689Z5-1]
DR MGI; MGI:2384298; Sbno1.
DR eggNOG; KOG1513; Eukaryota.
DR InParanoid; Q689Z5; -.
DR PhylomeDB; Q689Z5; -.
DR ChiTaRS; Sbno1; mouse.
DR PRO; PR:Q689Z5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q689Z5; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026937; SBNO_Helicase_C_dom.
DR InterPro; IPR026741; SNO.
DR InterPro; IPR039187; SNO_AAA.
DR PANTHER; PTHR12706; PTHR12706; 1.
DR Pfam; PF13872; AAA_34; 1.
DR Pfam; PF13871; Helicase_C_4; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Direct protein sequencing;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1390
FT /note="Protein strawberry notch homolog 1"
FT /id="PRO_0000314556"
FT REGION 21..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 840..867
FT /evidence="ECO:0000255"
FT COMPBIAS 696..719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 147
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 411
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 690
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 691
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 695
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 751
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 752
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 765
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 791
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 812
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 1219
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT MOD_RES 1383
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A3KN83"
FT VAR_SEQ 79
FT /note="Q -> QQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_030299"
FT CONFLICT 13
FT /note="L -> S (in Ref. 1; BAD38625)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="D -> G (in Ref. 1; BAD38625)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="T -> A (in Ref. 1; BAD38625)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="T -> A (in Ref. 1; BAD38625)"
FT /evidence="ECO:0000305"
FT CONFLICT 735
FT /note="S -> P (in Ref. 1; BAD38625)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1390 AA; 153738 MW; D811435E1E72CE02 CRC64;
MVEPGQDLLL AALSESGISP NDLFDVDGGD AGLATPTPPS VQQSVPLSAL ELGLETEAAV
PVKQEPEPMS TPALLNVRQP PSTTTFVLNQ INQLPTLGST IVMTKTPPAT TNRQTITLTK
FIQTTANTRP SVSAPAVRNA MPAAPSKDQV QLKDLLKNNS LNELMKLKPP ANIAQPVATA
ATDVSNGAVK KESSNKEVAR IWINDMKMRS FSPTMKVPVV KEEDEPEEED EEEMGHAETY
AEYMPIKLKI GLRHPDAVVE TSSLSSVTPP DVWYKTSISE ETIDNGWLSA LQLEAVTYAA
QQHETFLPNG DRAGFLIGDG AGVGKGRTIA GIIYENYLLS RKRALWFSVS NDLKYDAERD
LRDIGAKNIL VHSLNKFKYG KISSKHNGSV KKGVIFATYS SLIGESQSGG KYKTRLKQLL
HWCGDDFDGV IVFDECHKAK NLCPVGSSKP TKTGLAVLEL QNKLPKARVV YASATGASEP
RNMAYMNRLG IWGEGTPFRE FSDFIQAVER RGVGAMEIVA MDMKLRGMYI ARQLSFTGVT
FKIEEVLLSQ SYVKMYNKAV KLWVIARERF QQAADLIDAE QRMKKSMWGQ FWSAHQRFFK
YLCIASKVKR VVQLAREEIK NGKCVVIGLQ STGEARTLEA LEEGGGELND FVSTAKGVLQ
SLIEKHFPAP DRKKLYSLLG IDLTAPSNNS SPRDSPCKEN KIKKRKGEEI TREAKKARKV
GGLTGSSSDD SGSESVSDND ESDYESSKNM SSGDDDDFNP FRDESSEDNE DDPWLIRKDH
KKSKDKKKKK SIDPDSIQSA LLASGLGSKR PSFSSAPVIS PASNSAPANS NSNSNSSLVT
SQDAVERAQQ MKKDLLDKLE KLAEDLPPNT LDELIDELGG PENVAEMTGR KGRVVSNDDG
SISYESRSEL DVPVEILNIT EKQRFMDGDK NIAIISEAAS SGISLQADRR AKNQRRRVHM
TLELPWSADR AIQQFGRTHR SNQVTAPEYV FLISELAGEQ RFASIVAKRL EGLGALTHGD
RRATESRDLS RFNFDNKYGR NALEIVMKSI VNLDSPMVSP PPDYPGEFFK DVRQGLIGVG
LINVEDRSGI LTLDKDYNNI GKFLNRILGM EVHQQNALFQ YFADTLTAVV QNAKKSGRYD
MGILDLGSGD EKVRKSDVKK FLTPGYSTSG HVELYTISVE RGMSWEEATK IWAELTGPDD
GFYLSLQIRN NKKTAILVKE VNPKKKLFLI YRPNTGKQLK LEIYADLKKK YKKVVSDDAL
VHWLDQYNSS ADTCTHAYWR GNCKKASLGL VCEIGLRCRT YYVLCGSVLS VWTKVEGVLA
SVSGTNVKMQ IVRLRTEDGQ RIVGLIIPAN CVSPLVNLLS TSDQSQQLAV QQKQLWQQHH
PQSITNLSNL
