SBNO2_BOVIN
ID SBNO2_BOVIN Reviewed; 1374 AA.
AC A0JND4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein strawberry notch homolog 2;
GN Name=SBNO2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to have transcriptional repression activity in
CC macrophages. {ECO:0000250}.
CC -!- FUNCTION: Acts as a transcriptional coregulator, that can have both
CC coactivator and corepressor functions. Inhibits the DCSTAMP-repressive
CC activity of TAL1, hence enhancing the access of the transcription
CC factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in
CC bone homeostasis; required as a positive regulator in TNFSF11//RANKL-
CC mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be
CC required in the regulation of osteoblast differentiation. Involved in
CC the transcriptional corepression of NF-kappaB in macrophages. Plays a
CC role as a regulator in the pro-inflammatory cascade.
CC {ECO:0000250|UniProtKB:Q7TNB8, ECO:0000250|UniProtKB:Q9Y2G9}.
CC -!- SUBUNIT: Interacts with TAL1; this interaction inhibits TAL1 occupancy
CC of the DCSTAMP promoter, leading to the activation of the DCSTAMP
CC promoter by the transcription factor MITF.
CC {ECO:0000250|UniProtKB:Q7TNB8}.
CC -!- SIMILARITY: Belongs to the SBNO family. {ECO:0000305}.
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DR EMBL; BC126627; AAI26628.1; -; mRNA.
DR RefSeq; NP_001071379.1; NM_001077911.1.
DR AlphaFoldDB; A0JND4; -.
DR STRING; 9913.ENSBTAP00000027693; -.
DR PaxDb; A0JND4; -.
DR PRIDE; A0JND4; -.
DR Ensembl; ENSBTAT00000027693; ENSBTAP00000027693; ENSBTAG00000020780.
DR Ensembl; ENSBTAT00000074771; ENSBTAP00000073705; ENSBTAG00000020780.
DR GeneID; 512682; -.
DR KEGG; bta:512682; -.
DR CTD; 22904; -.
DR VEuPathDB; HostDB:ENSBTAG00000020780; -.
DR VGNC; VGNC:34309; SBNO2.
DR eggNOG; KOG1513; Eukaryota.
DR GeneTree; ENSGT00940000159946; -.
DR HOGENOM; CLU_000212_0_0_1; -.
DR InParanoid; A0JND4; -.
DR OMA; ARHSHKR; -.
DR OrthoDB; 141580at2759; -.
DR TreeFam; TF313526; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000020780; Expressed in neutrophil and 102 other tissues.
DR ExpressionAtlas; A0JND4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0061430; P:bone trabecula morphogenesis; IEA:Ensembl.
DR GO; GO:0071348; P:cellular response to interleukin-11; IEA:Ensembl.
DR GO; GO:0071354; P:cellular response to interleukin-6; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0002281; P:macrophage activation involved in immune response; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0030316; P:osteoclast differentiation; IBA:GO_Central.
DR GO; GO:0072675; P:osteoclast fusion; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR030410; SBNO2.
DR InterPro; IPR026937; SBNO_Helicase_C_dom.
DR InterPro; IPR026741; SNO.
DR InterPro; IPR039187; SNO_AAA.
DR PANTHER; PTHR12706; PTHR12706; 1.
DR PANTHER; PTHR12706:SF5; PTHR12706:SF5; 1.
DR Pfam; PF13872; AAA_34; 1.
DR Pfam; PF13871; Helicase_C_4; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 2: Evidence at transcript level;
KW Activator; Differentiation; Osteogenesis; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..1374
FT /note="Protein strawberry notch homolog 2"
FT /id="PRO_0000314559"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..203
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..643
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1374 AA; 150374 MW; ACE43E3F54C50CD3 CRC64;
MLAVGPAMDG ELPPHEAPPA GSVLYSPPPL QTPLCGPSVQ DTMLHYPWWN SFSPTTYPAF
SSESHQFMNS SFIMGQPCTD PSYGPAATAP SFPPKSSDFP QDSSYLDDLS NASIFSSSVD
SLSDIADTPD FPPADSLSQV PTIWDVSTGP SAHDKLFPPS GTFTGLEDPV SSLSSTPLLI
SYQAQSQPEE DDEAEEDEAE ELGHAETYAD YVPSKSKIGR QHPDRVVETS TLSSVPPPDI
TYTLALPSSD SGALSALQLE AITYACQQHE VLLPSGQRAG FLIGDGAGVG KGRTVAGVIL
ENYLRGRKKA LWFSVSNDLK YDAERDLRDI AAPGIAVHAL SKIKYGDNTT SEGVLFATYS
ALIGESQAGG QHRTRIRQIL EWCGEAFDGV IVFDECHKAK NASSTKMGKA VLDLQNKLPL
ARVVYASATG ASEPRNMIYM SRLGIWGEGT PFRTFEEFLH AIEKRGVGAM EIVAMDMKVS
GMYIARQLSF SGVTFRIEEI PLTPAFERIY NRAALLWAEA LGVFQQAADW IGLESRKSLW
GQFWSAHQRF FKYLCVAAKV HRLVELAQEE LAQDKCVVIG LQSTGEARTR EVLGEKEGQL
DGFVSAAEGV FLSLIQKHFP STKRRRERGA GSKRKRRPRG RGAKAPRLVY EAAGVIRISD
DSSTESDGGL DSDFHSSPES LLDDDVVIVD AIGLPADDRG PLCPPQRDLH GPGVLERVER
LKQDLLAKVQ ALGRELPVNT LDELIDQLGG PECVAEMTGR KGRVVSRPDG TVAFESRAEQ
GLSIDHVNLR EKERFMSGEK LVAIISEASS SGVSLQADRR VQNQRRRVHM TLELPWSADR
AIQQFGRTHR SNQVSAPEYI FLISELAGER RFASIVAKRL ESLGALTHGD RRATESRDLS
KYNFENKYGA RALSCVLTTI LSQTESKVPL PQGYPGGDAA FFRDMKQGLL SVGIGGRESR
SGCLDVEKDC SISKFLNRIL GLEVHKQNAL FQYFSDTFDH LIAADKREGK YDMGILDLAP
GIDEIYEESQ QVFLAPGHPQ DGQVVFYKIS VDRGLKWEEA YARSLELTGT HDGFYLSYKV
RGNKPSCLLA QQNRGKLFTV YKPNIGRQSQ LESLDSLSRR FRRVTAEEAR EPWESSYTFS
LTHCSHTTWN RHCRLVQEGK DCAQGLRLRH HYMLCGALLR VWGRIAAVMA DVTSSSYLQI
VRLKTKDKKK QVGIKIPEVC VRRVLQELQL MDADVKRKQA RTRGLLAPPS TPRPLALPFG
PGEVLDLTYS PPAQAFPAPS PFTFPALGPG PGGQLLGAPD TPDAPADPVA LLHQGCEINF
KEVLEDMLRS LNAAPPAEPP GPLGPLGAGA AGAPAGGAPE RQSVIQFSPP FPNS
