ID   SBP1A_XENLA             Reviewed;         472 AA.
AC   Q52KZ7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Methanethiol oxidase {ECO:0000250|UniProtKB:Q13228};
DE            Short=MTO {ECO:0000250|UniProtKB:Q13228};
DE            EC=1.8.3.4 {ECO:0000250|UniProtKB:Q13228};
DE   AltName: Full=Selenium-binding protein 1-A;
GN   Name=selenbp1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the oxidation of methanethiol, an organosulfur
CC       compound known to be produced in substantial amounts by gut bacteria
CC       (By similarity). Selenium-binding protein which may be involved in the
CC       sensing of reactive xenobiotics in the cytoplasm. May be involved in
CC       intra-Golgi protein transport (By similarity).
CC       {ECO:0000250|UniProtKB:Q13228, ECO:0000250|UniProtKB:Q8VIF7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 +
CC         hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4;
CC         Evidence={ECO:0000250|UniProtKB:Q13228};
CC   -!- PATHWAY: Organosulfur degradation. {ECO:0000250|UniProtKB:Q13228}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol
CC       {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenium-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC094129; AAH94129.1; -; mRNA.
DR   RefSeq; NP_001089396.1; NM_001095927.1.
DR   AlphaFoldDB; Q52KZ7; -.
DR   SMR; Q52KZ7; -.
DR   DNASU; 734446; -.
DR   GeneID; 734446; -.
DR   KEGG; xla:734446; -.
DR   CTD; 734446; -.
DR   Xenbase; XB-GENE-959080; selenbp1.L.
DR   OMA; FDSEFNC; -.
DR   OrthoDB; 483905at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734446; Expressed in zone of skin and 11 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018549; F:methanethiol oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008430; F:selenium binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR008826; Se-bd.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR23300; PTHR23300; 1.
DR   Pfam; PF05694; SBP56; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Oxidoreductase; Protein transport;
KW   Reference proteome; Selenium; Transport.
FT   CHAIN           1..472
FT                   /note="Methanethiol oxidase"
FT                   /id="PRO_0000289065"
SQ   SEQUENCE   472 AA;  52614 MW;  6C16EB92DCB4BC58 CRC64;
     MAKCGSCGPG YKSPLDAMKG PREEIVYLPC IYRSTGINKP DYLATVDVDP KSPSYSQVIH
     RLPMPNVNDE LHHSGWNTCS SCYGDSSKVR NKLILPCLIS SRIYVVDVGS DPRAPRIHKT
     VEPYEVFWKC GLANPHTSHC LGCGEIMISS LGDPCGNGKG GFVLLDGETF EVKGNWEVEG
     ESAQFGYDFW YQPRHNVMIS TEWGAPKAFA LGFKMEDVQA GHYGHSLNVW DWTEHRLVQT
     IDLGKDGLIP LEIRFLHNPD ADQGLVGCAL SSSIFRFYKE KDGKWAAEKV IQVPSKKVEG
     WPMPEMPGLI TDILISLDDR FLYFSNWLHG DIRQYDITDT RNPKLVGQIF LGGSIQRGGP
     VTVLEDKELE CQPDPVTVKG KIIPGGPQMI QLSLDGKRIY VTSSLYSIWD KQFYPDLLKE
     GAVMLQIDVD TKKGGLKLNP NFLVDFGKEP DGPVLAHEIR YPGGDCTSDI WI