ID   SBP1B_XENLA             Reviewed;         472 AA.
AC   Q6DCH7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Methanethiol oxidase {ECO:0000250|UniProtKB:Q13228};
DE            Short=MTO {ECO:0000250|UniProtKB:Q13228};
DE            EC=1.8.3.4 {ECO:0000250|UniProtKB:Q13228};
DE   AltName: Full=Selenium-binding protein 1-B;
GN   Name=selenbp1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the oxidation of methanethiol, an organosulfur
CC       compound known to be produced in substantial amounts by gut bacteria
CC       (By similarity). Selenium-binding protein which may be involved in the
CC       sensing of reactive xenobiotics in the cytoplasm. May be involved in
CC       intra-Golgi protein transport (By similarity).
CC       {ECO:0000250|UniProtKB:Q13228, ECO:0000250|UniProtKB:Q8VIF7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 +
CC         hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4;
CC         Evidence={ECO:0000250|UniProtKB:Q13228};
CC   -!- PATHWAY: Organosulfur degradation. {ECO:0000250|UniProtKB:Q13228}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol
CC       {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenium-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC078056; AAH78056.1; -; mRNA.
DR   RefSeq; NP_001087138.1; NM_001093669.1.
DR   AlphaFoldDB; Q6DCH7; -.
DR   SMR; Q6DCH7; -.
DR   MaxQB; Q6DCH7; -.
DR   DNASU; 447027; -.
DR   GeneID; 447027; -.
DR   KEGG; xla:447027; -.
DR   CTD; 447027; -.
DR   Xenbase; XB-GENE-6254577; selenbp1.S.
DR   OMA; DETCQSP; -.
DR   OrthoDB; 483905at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 447027; Expressed in internal ear and 20 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018549; F:methanethiol oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008430; F:selenium binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR008826; Se-bd.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR23300; PTHR23300; 1.
DR   Pfam; PF05694; SBP56; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Oxidoreductase; Protein transport;
KW   Reference proteome; Selenium; Transport.
FT   CHAIN           1..472
FT                   /note="Methanethiol oxidase"
FT                   /id="PRO_0000289066"
SQ   SEQUENCE   472 AA;  52509 MW;  53579F5FF708DE0C CRC64;
     MAKCGSCGPG YKSPLDAMKG PREEIVYLPC IYRSTGINKP DYLATVDVDP KSPTYSQVIH
     RLPMPNVNDE LHHSGWNTCS SCYGDSSKVR NKLILPCLIS SRVYVVDVGT DPRAPRLHKT
     VEPHEVYWKC GLANLHTSHC LGCGEIMISA LGDPCGNGKG GFVLLDGETF EVKGNWEAEG
     ETAQFGYDFW YQPRHNVMIS TEWGAPKAFA LGFKMEDVLA GQYGHSLNVW DWTEHRLVQT
     IDLGKDGLIP LEIRFLHNPD ADQGLVGCAL SSSIFRFYKE KDGKWAAEKV IQVPSKKVEG
     WALPEMPGLI TDILISLDDR FLYFSNWLHG DIRQYDITNI RNPKLVGQIF LGGSIQKGGP
     VAVQEDKELE CQPDPVTVKG KIIPGGPQMI QLSLDGKRIY VTSSIYSIWD KQFYPDMLKE
     GAVMLQIDVD TEKGGLKLNP NFLVDFGKEP DGPVLAHELR YPGGDCSSDI WI