ID   SBP1_DANRE              Reviewed;         457 AA.
AC   Q6PHD9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Methanethiol oxidase {ECO:0000250|UniProtKB:Q13228};
DE            Short=MTO {ECO:0000250|UniProtKB:Q13228};
DE            EC=1.8.3.4 {ECO:0000250|UniProtKB:Q13228};
DE   AltName: Full=Selenium-binding protein 1;
GN   Name=selenbp1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the oxidation of methanethiol, an organosulfur
CC       compound known to be produced in substantial amounts by gut bacteria
CC       (By similarity). Selenium-binding protein which may be involved in the
CC       sensing of reactive xenobiotics in the cytoplasm. May be involved in
CC       intra-Golgi protein transport (By similarity).
CC       {ECO:0000250|UniProtKB:Q13228, ECO:0000250|UniProtKB:Q8VIF7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 +
CC         hydrogen sulfide; Xref=Rhea:RHEA:11812, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16007,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:29919; EC=1.8.3.4;
CC         Evidence={ECO:0000250|UniProtKB:Q13228};
CC   -!- PATHWAY: Organosulfur degradation. {ECO:0000250|UniProtKB:Q13228}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13228}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13228}. Membrane
CC       {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q8VIF7}.
CC   -!- SIMILARITY: Belongs to the selenium-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC056590; AAH56590.1; -; mRNA.
DR   RefSeq; NP_956864.1; NM_200570.1.
DR   AlphaFoldDB; Q6PHD9; -.
DR   SMR; Q6PHD9; -.
DR   STRING; 7955.ENSDARP00000116604; -.
DR   PaxDb; Q6PHD9; -.
DR   PRIDE; Q6PHD9; -.
DR   GeneID; 393542; -.
DR   KEGG; dre:393542; -.
DR   CTD; 8991; -.
DR   ZFIN; ZDB-GENE-040426-1436; selenbp1.
DR   eggNOG; KOG0918; Eukaryota.
DR   InParanoid; Q6PHD9; -.
DR   OrthoDB; 483905at2759; -.
DR   PhylomeDB; Q6PHD9; -.
DR   PRO; PR:Q6PHD9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018549; F:methanethiol oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008430; F:selenium binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008826; Se-bd.
DR   PANTHER; PTHR23300; PTHR23300; 1.
DR   Pfam; PF05694; SBP56; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Oxidoreductase; Protein transport;
KW   Reference proteome; Selenium; Transport.
FT   CHAIN           1..457
FT                   /note="Methanethiol oxidase"
FT                   /id="PRO_0000289064"
SQ   SEQUENCE   457 AA;  50983 MW;  BA8347256F474DB9 CRC64;
     MASTCSGCGP GYKTPLDAMK GPREEIVYLP CIYRNTDIQK PDYLATVDIN PQSPNFCKVI
     HRLPMPNLKD ELHHSGWNAC SSCFDDPSKR RNRLILPSLI SSRIYVVDVG TDPRAPRLHK
     TVEPTDLFWK CGLANPHTSH CLGSGQIMIS TMGDPSGNGK GGFVLLDGET FEVIGNWEQP
     GDAAPFGYDF WYQPRHNVMI STEWGAPKAL GNGFNPADVK AGHYGQRLHV WDWTTHKRIQ
     TLDLGEEGAI PLEVRFLHDP AAAEGFVGCA LQSTVFRFYK TPKGDWAAEK VIKVPSKKVE
     GWALPDMPGL ITDILISLDD RFLYFSNWLH GDIRQYDITD RKNPRMVGQV FLGGSVLKDG
     PVKVLEDKEL DSQPTPRILK GKRLYVTTSL YSAWDKQFYP DLIKEGSVMM QIDVNTDTGG
     LKLNENFLVD FGAEPEGPAL AHELRYPGGD CTSDIWL